{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:46:08Z","timestamp":1760888768959},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,2,14]],"date-time":"2013-02-14T00:00:00Z","timestamp":1360800000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2013,2]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Parenteral nutrition (PN<\/jats:styled-content>)\u2010associated liver dysfunction (PNALD<\/jats:styled-content>) in term infants usually manifests as intrahepatic cholestasis, which recovers with enteral nutrition (EN<\/jats:styled-content>) in most cases; however, as the number of extremely low\u2010birthweight infants (ELBWI<\/jats:styled-content>) has been increasing, and consequently intestinal diseases associated with ELBWI<\/jats:styled-content> have been increasing, more intractable PNALD<\/jats:styled-content> has been encountered after surgical treatment in ELBWI<\/jats:styled-content>, which does not resolve or rather worsens with EN<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Three cases of ELBWI<\/jats:styled-content> with intestinal perforation, which developed PNALD<\/jats:styled-content> and eventually died of hepatic failure with intractable portal hypertension, were reviewed. Their gestational age and birthweight ranged from 23 to 26 weeks, and from 434 to 968\u2009g, respectively. The intestinal diseases included necrotizing enteritis in two and meconium\u2010related ileus with focal intestinal perforation in one.<\/jats:p><\/jats:sec>Results<\/jats:title>The duration of total PN<\/jats:styled-content> without EN<\/jats:styled-content> in the three cases was 17, 24 and 24 days, respectively. The interval between the introduction of PN<\/jats:styled-content> and the onset of PNALD<\/jats:styled-content> was 14, 4 and 18 days, respectively. A marked elevation of serum endotoxin level was detected in both cases of necrotizing enteritis. Histopathological study of the liver revealed marked cholestasis, significant hepatic necrosis with fibrosis, and proliferation of ductules in all these cases, which was responsible for portal hypertension.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>PN<\/jats:styled-content> after gastrointestinal disorders in ELBWI<\/jats:styled-content> may cause refractory PNALD<\/jats:styled-content>, which does not resolve, or rather worsens with the resumption of EN<\/jats:styled-content>. Portal hypertension secondary to hepatic necrosis may be responsible for the exacerbation with the resumption of EN<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12026","type":"journal-article","created":{"date-parts":[[2012,12,13]],"date-time":"2012-12-13T13:19:17Z","timestamp":1355404757000},"page":"39-43","source":"Crossref","is-referenced-by-count":7,"title":["Parenteral\u2010nutrition\u2010associated liver disease after intestinal perforation in extremely low\u2010birthweight infants: Consequent lethal portal hypertension"],"prefix":"10.1111","volume":"55","author":[{"given":"Akio","family":"Kubota","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narutaka","family":"Mochizuki","sequence":"additional","affiliation":[{"name":"Department of Neonatology Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Shiraishi","sequence":"additional","affiliation":[{"name":"Department of Neonatology Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Pathology Osaka Medical Center and Research Institute for Maternal and Child Health Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisayoshi","family":"Kawahara","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Yoneda","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Tazuke","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taro","family":"Goda","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kengo","family":"Nakahata","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Sano","sequence":"additional","affiliation":[{"name":"Department of Neonatology Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Hirano","sequence":"additional","affiliation":[{"name":"Department of Neonatology Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Kitajima","sequence":"additional","affiliation":[{"name":"Department of Neonatology Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,2,14]]},"reference":[{"key":"e_1_2_4_2_1","first-page":"101","article-title":"Neonatal surgery in Japan \u2013 national survey on neonatal surgery 2008","volume":"46","author":"Committee on Academic Survey and Advanced Medical Science","year":"2010","journal-title":"J. Jpn. Soc. Pediatr. Surg."},{"key":"e_1_2_4_3_1","first-page":"44","volume-title":"Live Births and Percentages by Birth Weight and Sex, 1951\u20132005. Maternal and Child Health Statistics of Japan","author":"Mothers' & Children's Health & Welfare Association","year":"2007"},{"key":"e_1_2_4_4_1","first-page":"21","volume-title":"A Multicenter Benchmark Research on Neonatal Outcome in Japan","author":"Fujimura M","year":"2010"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(98)90475-4"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003830050668"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2000.18299"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-002-0839-7"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-007-1984-9"},{"key":"e_1_2_4_10_1","first-page":"120","article-title":"Meconium related ileus in a perinatal referring center","volume":"31","author":"Kubota A","year":"1995","journal-title":"J. Jpn. Soc. Neonatol."},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1072290"},{"key":"e_1_2_4_12_1","first-page":"1193","article-title":"Long\u2010term outcome of meconium\u2010related ileus","volume":"32","author":"Kubota A","year":"2000","journal-title":"Jpn. J. Pediatr. Surg."},{"key":"e_1_2_4_13_1","first-page":"609","article-title":"Pathology and pathophysiology of meconium\u2010related ileus","volume":"38","author":"Kubota A","year":"2006","journal-title":"Jpn. J. Pediatr. Surg."},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2011.03381.x"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.76.2.F101"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-1463"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607189013006586"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2005.03.019"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607100024005270"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607104028006431"},{"key":"e_1_2_4_21_1","first-page":"185","article-title":"Total parenteral nutrition promotes bacterial translocation from the gut","volume":"104","author":"Alverdy JC","year":"1988","journal-title":"Surgery"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2000.01535.x"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e318142580a"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2004.tb02636.x"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(00)90005-8"},{"key":"e_1_2_4_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.06.086"},{"key":"e_1_2_4_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(88)80185-9"},{"key":"e_1_2_4_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(98)90352-9"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.12026","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.12026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T03:33:04Z","timestamp":1697254384000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.12026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["10.1111\/ped.12026"],"URL":"https:\/\/doi.org\/10.1111\/ped.12026","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2]]}}}