{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T22:00:41Z","timestamp":1774476041370,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,6,18]],"date-time":"2013-06-18T00:00:00Z","timestamp":1371513600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sepsis caused by <jats:styled-content style=\"fixed-case\">g<\/jats:styled-content>roup <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> streptococcus has been well controlled with aminobenzylpenicillin, but the incidence of <jats:italic><jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>scherichia coli<\/jats:italic> sepsis has increased in proportion. <jats:italic>E.\u2009coli<\/jats:italic> is a <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>ram\u2010negative bacillus associated with poor prognosis due to the release of endotoxins. Conventional treatment with antibiotics alone may not be sufficient because the inflammatory response exacerbates the unstable hemodynamic status. Polymyxin <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> hemoperfusion has been established as a treatment option for septic shock in adults. Polymyxin <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> hemoperfusion adsorbs endotoxins and cannabinoids such as anandamide and 2\u2010arachidonoylglycerol. Reported herein is a case of severe septic shock induced by <jats:italic><jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>.\u2009coli<\/jats:italic>. The concomitant use of polymyxin <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> hemoperfusion rapidly reduced the requirement for catecholamines and the patient was discharged without short\u2010term neurological or respiratory sequelae. It is suggested that polymyxin <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> hemoperfusion might be an innovative therapy for severe sepsis, and could improve outcome.<\/jats:p>","DOI":"10.1111\/ped.12029","type":"journal-article","created":{"date-parts":[[2013,6,19]],"date-time":"2013-06-19T03:25:44Z","timestamp":1371612344000},"source":"Crossref","is-referenced-by-count":13,"title":["Septic neonate rescued by <scp>p<\/scp>olymyxin <scp>B<\/scp> hemoperfusion"],"prefix":"10.1111","volume":"55","author":[{"given":"Eiji","family":"Hirakawa","sequence":"first","affiliation":[{"name":"Division of Neonatology Perinatal Medical Center Kagoshima City Hospital  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Ibara","sequence":"additional","affiliation":[{"name":"Division of Neonatology Perinatal Medical Center Kagoshima City Hospital  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Tokuhisa","sequence":"additional","affiliation":[{"name":"Division of Neonatology Perinatal Medical Center Kagoshima City Hospital  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayuri","family":"Hiwatashi","sequence":"additional","affiliation":[{"name":"Division of Neonatology Perinatal Medical Center Kagoshima City Hospital  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Hayashida","sequence":"additional","affiliation":[{"name":"Division of Neonatology Perinatal Medical Center Kagoshima City Hospital  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinobu","family":"Maede","sequence":"additional","affiliation":[{"name":"Division of Neonatology Perinatal Medical Center Kagoshima City Hospital  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takako","family":"Matsui","sequence":"additional","affiliation":[{"name":"Division of Neonatology Perinatal Medical Center Kagoshima City Hospital  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Nakazawa","sequence":"additional","affiliation":[{"name":"Division of Neonatology Perinatal Medical Center Kagoshima City Hospital  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Inoue","sequence":"additional","affiliation":[{"name":"Division of Neonatology Perinatal Medical Center Kagoshima City Hospital  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Kodaira","sequence":"additional","affiliation":[{"name":"Division of Neonatology Perinatal Medical Center Kagoshima City Hospital  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,18]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PCC.0000149131.72248.E6"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.20287"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-005-0366-5"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2008.00612.x"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.shk.0000159930.87737.8a"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc3890"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc5780"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.856"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(10)70220-6"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.12.11.1035"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-007-0056-6"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.12029","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.12029","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T18:56:37Z","timestamp":1697309797000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.12029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.1111\/ped.12029"],"URL":"https:\/\/doi.org\/10.1111\/ped.12029","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6]]}}}