{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:05:15Z","timestamp":1761581115166},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,8,5]],"date-time":"2013-08-05T00:00:00Z","timestamp":1375660800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2013,8]]},"abstract":"Abstract<\/jats:title>Brain abscesses are uncommon complications of bacterial meningitis or sepsis in neonates and infants. The causative pathogens of brain abscess in newborns are various. Of those, E<\/jats:styled-content>scherichia coli<\/jats:italic> is rarely seen as a pathogen in brain abscess at this age. Herein we reported brain abscesses in twin infants caused by E<\/jats:styled-content>.\u2009coli<\/jats:italic> sepsis. Interestingly, genetic analysis identified heterozygous T<\/jats:styled-content>oll\u2010like receptor 4 (TLR<\/jats:styled-content>4<\/jats:italic>) gene mutation in the twins. Because TLR<\/jats:italic><\/jats:styled-content> plays an important role in the natural response to bacterial products and initiates specific immune response against these pathogens, this may explain the development of brain abscess in the present case.<\/jats:p>","DOI":"10.1111\/ped.12032","type":"journal-article","created":{"date-parts":[[2013,8,5]],"date-time":"2013-08-05T08:19:41Z","timestamp":1375690781000},"page":"516-518","source":"Crossref","is-referenced-by-count":5,"title":["E<\/scp>scherichia coli<\/i> brain abscess in a twin pair associated with TLR<\/scp>4<\/i> gene mutation"],"prefix":"10.1111","volume":"55","author":[{"given":"Aydin","family":"Erdemir","sequence":"first","affiliation":[{"name":"Neonatology Clinic Tepecik Training and Research Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zelal","family":"Kahramaner","sequence":"additional","affiliation":[{"name":"Neonatology Clinic Tepecik Training and Research Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hese","family":"Cosar","sequence":"additional","affiliation":[{"name":"Neonatology Clinic Tepecik Training and Research Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebru","family":"Turkoglu","sequence":"additional","affiliation":[{"name":"Neonatology Clinic Tepecik Training and Research Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumer","family":"Sutcuoglu","sequence":"additional","affiliation":[{"name":"Neonatology Clinic Tepecik Training and Research Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilara Kocacik","family":"Uygun","sequence":"additional","affiliation":[{"name":"Department of Pediatric Immunology School of Medicine Akdeniz University Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olcay","family":"Yegin","sequence":"additional","affiliation":[{"name":"Department of Pediatric Immunology School of Medicine Akdeniz University Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afig","family":"Berdeli","sequence":"additional","affiliation":[{"name":"School of Medicine Department of Pediatrics Ege University Izmir"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esra Arun","family":"Ozer","sequence":"additional","affiliation":[{"name":"Neonatology Clinic Tepecik Training and Research Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8,5]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1988.69.6.0877"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.04076.x"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073809338326"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2004.03.010"},{"key":"e_1_2_4_6_1","first-page":"727","article-title":"Escherichia coli brain abscess in a very low birthweight premature infant","volume":"4","author":"Makhoul IR","year":"2002","journal-title":"Isr. 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