{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T19:16:33Z","timestamp":1770146193309,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,4,16]],"date-time":"2013-04-16T00:00:00Z","timestamp":1366070400000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2013,4]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The aim of this study was to investigate the incidence and risk factors of peripherally inserted central venous catheter (PICC<\/jats:styled-content>)\u2010related complications using a multicenter case survey.<\/jats:p><\/jats:sec>Method<\/jats:title>A prospective cohort study was carried out by 19 neonatal intensive care units (NICUs)<\/jats:styled-content> in J<\/jats:styled-content>apan from F<\/jats:styled-content>ebruary 2005 to M<\/jats:styled-content>arch 2007. A total of 975 case records were collected. PICC<\/jats:styled-content>\u2010related complications including pericardial effusion\/cardiac tamponade pleural effusion\/ascites, catheter removal difficulties, catheter\u2010related bloodstream infection (CR\u2010BSI<\/jats:styled-content>), and symptomatic catheter\u2010related thrombosis were collected from case record forms. As for precautions during insertion, institutions were classified into three groups: those with maximum barrier precautions; standard precautions; and no specific precautions.<\/jats:p><\/jats:sec>Results<\/jats:title>PICC<\/jats:styled-content> complications occurred in 27 cases (2.9%) among 946 PICC<\/jats:styled-content>. The incidence was 1.6% for CR\u2010BSI<\/jats:styled-content>, and 0.1% for cardiac tamponade. CR\u2010BSI<\/jats:styled-content> rate per 1000 catheter\u2010days was 1.1 with maximum barrier precautions at catheter insertion, 1.2 with standard precautions, and 1.8 with no specific precautions. Multiple logistic regression analysis showed that proximal placement (odds ratio [OR]<\/jats:styled-content>, 3.88; 95% confidence interval [CI]:<\/jats:styled-content> 1.42\u201310.60, P<\/jats:italic> = 0.008) and longer placement duration (OR<\/jats:styled-content>, 1.35; 95%CI<\/jats:styled-content>: 1.14\u20131.60, for each week, P<\/jats:italic> = 0.0005) independently contributed to overall complications.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The incidence of cardiac tamponade was rare in this multicenter prospective study. Longer duration and proximal placement may be risk factors for PICC<\/jats:styled-content> complications. In this cohort, the CR\u2010BSI<\/jats:styled-content> rate was low irrespective of the degree of barrier precautions at insertion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12033","type":"journal-article","created":{"date-parts":[[2012,12,18]],"date-time":"2012-12-18T18:33:08Z","timestamp":1355855588000},"page":"185-189","source":"Crossref","is-referenced-by-count":52,"title":["Complications of peripherally inserted central venous catheter in J<\/scp>apanese neonatal intensive care units"],"prefix":"10.1111","volume":"55","author":[{"given":"Yasushi","family":"Ohki","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Developmental Medicine Gunma University Graduate School of Medicine Maebashi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Departmen of Neonatology Gunma Children's Medical Center Shibukawa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Harigaya","sequence":"additional","affiliation":[{"name":"Deparment of Pediatrics Kiryu Kosei General Hospital Kiryu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miyuki","family":"Kohno","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Developmental Medicine Gunma University Graduate School of Medicine Maebashi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirokazu","family":"Arakawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Developmental Medicine Gunma University Graduate School of Medicine Maebashi"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,4,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.049189"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2008.02639.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.88.4.F292"},{"key":"e_1_2_6_5_1","first-page":"1","article-title":"Guidelines for the prevention of intravascular catheter\u2010related infections. 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