{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:44:38Z","timestamp":1790189078336,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,6,18]],"date-time":"2013-06-18T00:00:00Z","timestamp":1371513600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to identify predictors of neurologic damage in children with febrile seizures or altered consciousness within 6\u2009h of seizure onset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The present study included 86 children (age range, 4\u2013159 months old), who fulfilled the diagnostic criteria for complex febrile seizures on admission between <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>ctober 2002 and <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ovember 2008. Using the <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ediatric <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>erebral <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>erformance <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ategory <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>cale (<jats:styled-content style=\"fixed-case\">PCPC<\/jats:styled-content>), the children were classified into two groups: poor outcome (<jats:styled-content style=\"fixed-case\">PCPC<\/jats:styled-content> = 2\u20136) and good outcome (<jats:styled-content style=\"fixed-case\">PCPC<\/jats:styled-content> = 1). Clinical profiles and laboratory findings were compared between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 86 children, 17 fell into the poor outcome and 69 into the good outcome group. Using univariate analysis, three early risk factors for poor outcome were identified: (i) consciousness disturbance or hemiplegia at 6\u2009h from onset; (ii) refractory status epilepticus; and (iii) elevation of aspartate aminotransferase to &gt;90\u2009<jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\/L within 6\u2009h of onset. Using these criteria, children in the poor outcome group were identified with a 94% sensitivity and 67% specificity rate (odds ratio, 36.6; 95% confidence interval: 4.87\u20131560). During the study period, the inpatients who met the criteria for acute encephalopathy also fell into the poor outcome group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The development of neurologic damage in children with complex febrile seizures can be predicted within 6\u2009h of onset, using the identified risk factors. The authors propose an assumption of severe febrile seizures (<jats:styled-content style=\"fixed-case\">SFS<\/jats:styled-content>) in children who fulfill these risk factors. Using <jats:styled-content style=\"fixed-case\">SFS<\/jats:styled-content> as an inclusion criterion, an interventional study for acute encephalopathy can be designed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12046","type":"journal-article","created":{"date-parts":[[2013,1,2]],"date-time":"2013-01-02T10:27:26Z","timestamp":1357122446000},"page":"310-314","source":"Crossref","is-referenced-by-count":31,"title":["Therapeutic indicators of acute encephalopathy in patients with complex febrile seizures"],"prefix":"10.1111","volume":"55","author":[{"given":"Hiroaki","family":"Nagase","sequence":"first","affiliation":[{"name":"Department of Neurology Hyogo Prefectural Kobe Children's Hospital  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taku","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Hyogo Prefectural Kobe Children's Hospital  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunori","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Hyogo Prefectural Kobe Children's Hospital  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoko","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Neurology Hyogo Prefectural Kobe Children's Hospital  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohsuke","family":"Saji","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Hyogo Prefectural Kobe Children's Hospital  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azusa","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Department of Neurology Hyogo Prefectural Kobe Children's Hospital  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Uetani","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Hyogo Prefectural Kobe Children's Hospital  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,18]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2007.00809.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1542\/peds.66.6.1009a","article-title":"Consensus statement. Febrile seizures: long\u2010term management of children with fever\u2010associated seizures","volume":"66","year":"1980","journal-title":"Pediatrics"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e318162a13b"},{"key":"e_1_2_5_5_1","first-page":"773","article-title":"Neurologic complications associated with novel influenza A (H1N1) virus infection in children \u2013 Dallas, Texas, May 2009","volume":"58","year":"2009","journal-title":"MMWR Morb. Mortal. Wkly Rep."},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(96)00063-0"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000210487.36667.a5"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2005.08.002"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1981.03320210015014"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneuro0922"},{"key":"e_1_2_5_11_1","first-page":"858","article-title":"Therapeutic indication for acute encephalopathy using predictors in patients with complex febrile seizures (Japanese)","volume":"114","author":"Nagase H","year":"2010","journal-title":"J. Japan Pediatr. Soc."},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.61.5.720"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2005.078436"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)82544-2"},{"key":"e_1_2_5_15_1","first-page":"277","volume-title":"Epileptic Syndromes in Infancy, Childhood and Adolescence","author":"Patrick Chauvel CD","year":"2005"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90057-0"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2009.01198.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/08830738050200030301"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2007.05.007"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02535.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31816507b2"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000073864"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2009.180554"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2004.08.017"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-955928"},{"key":"e_1_2_5_26_1","first-page":"211","article-title":"Unilateral seizures: Hemiconvulsions\u2010hemiplegia syndrome (HH) and hemiconvulsions\u2010hemiplegia\u2010epilepsy syndrome (HHE)","volume":"35","author":"Roger J","year":"1982","journal-title":"Electroencephalogr. Clin. Neurophysiol. Suppl."},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2007.00811.x"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.12046","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.12046","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T18:55:45Z","timestamp":1697309745000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.12046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.1111\/ped.12046"],"URL":"https:\/\/doi.org\/10.1111\/ped.12046","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6]]}}}