{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T15:18:43Z","timestamp":1789399123535,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,6,18]],"date-time":"2013-06-18T00:00:00Z","timestamp":1371513600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2013,6]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Respiratory syncytial virus (RSV<\/jats:styled-content>) is the main cause of severe acute respiratory infection (SARI<\/jats:styled-content>) in infants and young children. This study aimed to identify risk factors for intensive care unit (ICU<\/jats:styled-content>) admission, prolonged length of stay (PLOS<\/jats:styled-content>), and mortality in patients hospitalized with SARI<\/jats:styled-content> caused by RSV<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>This prospective cohort study included children hospitalized with SARI<\/jats:styled-content> (according to the W<\/jats:styled-content>orld H<\/jats:styled-content>ealth O<\/jats:styled-content>rganization definition) and whose laboratory results proved RSV<\/jats:styled-content> infection during the period from F<\/jats:styled-content>ebruary 2010 to M<\/jats:styled-content>ay 2011.<\/jats:p><\/jats:sec>Results<\/jats:title>Out of 240 enrolled patients, 24 patients (10%) were admitted to the ICU<\/jats:styled-content>, 57 patients (24.3%) had a PLOS<\/jats:styled-content> of >9 days and 12 patients (5%) died. The presence of cyanosis (P<\/jats:italic> = 0.000; OR<\/jats:styled-content>, 351.7) and lung consolidation (P<\/jats:italic> = 0.006, OR<\/jats:styled-content>, 9.3) were independent risk factors associated with ICU<\/jats:styled-content> admission. The need for ICU<\/jats:styled-content> admission (P<\/jats:italic> = 0.000; OR<\/jats:styled-content>, 6.1) and lung consolidation (P<\/jats:italic> = 0.008, OR<\/jats:styled-content>, 2.46) were independent risk factors associated with PLOS<\/jats:styled-content>. The presence of an underlying congenital heart disease (P<\/jats:italic> = 0.03, OR<\/jats:styled-content>, 18.3), thrombocytopenia (P<\/jats:italic> = 0.04, OR<\/jats:styled-content>, 32.86) and mechanical ventilation (P<\/jats:italic> = 0.000; OR<\/jats:styled-content>, 449.4) were the only independent risk factors associated with mortality in our study.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Early recognition of risk factors for complicated RSV<\/jats:styled-content> disease on admission prompts early interventions and early ICU<\/jats:styled-content> admissions for these children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12051","type":"journal-article","created":{"date-parts":[[2013,1,14]],"date-time":"2013-01-14T14:16:27Z","timestamp":1358172987000},"page":"283-288","source":"Crossref","is-referenced-by-count":26,"title":["Morbidity and outcome of severe respiratory syncytial virus infection"],"prefix":"10.1111","volume":"55","author":[{"given":"Amani A.","family":"El Kholy","sequence":"first","affiliation":[{"name":"Departments of Clinical and Chemical Pathology Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia A.","family":"Mostafa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seham A.","family":"El\u2010Sherbini","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliaa A.","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reem I.","family":"Ismail","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rania I.","family":"Magdy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona S.","family":"Hamdy","sequence":"additional","affiliation":[{"name":"Departments of Clinical and Chemical Pathology Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"May S.","family":"Soliman","sequence":"additional","affiliation":[{"name":"Departments of Clinical and Chemical Pathology Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,18]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199308000-00007"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/rmed.2002.1294"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20768"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yapd.2009.08.019"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0804877"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31805d01e3"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.104.3.463"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1995.02170240035005"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.2.179"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)90000-0"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198208123070702"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.100.6.943"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00130478-200110000-00006"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2004.03.013"},{"key":"e_1_2_5_16_1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1542\/peds.81.1.22","article-title":"Prediction of the duration of hospitalization in patients with respiratory syncytial virus infection: use of clinical parameters","volume":"81","author":"McMillan JA","year":"1988","journal-title":"Pediatrics"},{"key":"e_1_2_5_17_1","unstructured":"WHO Regional Office for Europe.Guidance for Influenza Surveillance in Humans. 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