{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T21:33:39Z","timestamp":1775165619488,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,6,18]],"date-time":"2013-06-18T00:00:00Z","timestamp":1371513600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2013,6]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The angiotensin type 2 receptor plays a unique role in growth inhibition in adult myocardium via modulation of ceramide synthesis. Angiotensin type 1 (AT<\/jats:styled-content>1<\/jats:sub><\/jats:styled-content>)\u2010receptor blockade results in increased angiotensin type 2 receptor activation by angiotensin II<\/jats:styled-content>, and AT<\/jats:styled-content>1<\/jats:sub><\/jats:styled-content>\u2010receptor blockers are sometimes prescribed to children for the treatment of cardiac hypertrophy or heart failure. We investigated the changes of ceramide lipid components in hypertrophied immature rabbit hearts after chronic administration of the AT<\/jats:styled-content>1<\/jats:sub><\/jats:styled-content>\u2010receptor blocker, losartan.<\/jats:p><\/jats:sec>Methods<\/jats:title>One\u2010week\u2010old Japanese white rabbits were randomly divided into three groups: sham\u2010operated control rabbits (Group S<\/jats:styled-content>), rabbits given distilled water orally for 21 days after aortic constriction (Group H<\/jats:styled-content>), and rabbits given losartan orally for 21 days after aortic constriction (Group H + L<\/jats:styled-content>).<\/jats:p><\/jats:sec>Results<\/jats:title>Compared with Group S<\/jats:styled-content>, the hypertrophy index and left ventricular posterior wall thickness were significantly increased in Group H<\/jats:styled-content>, but were not different in Group H + L<\/jats:styled-content>. Total myocardial ceramide levels in Group H<\/jats:styled-content> and Group H + L<\/jats:styled-content> were suppressed compared with Group S<\/jats:styled-content>. The relative fatty acid components of myocardial ceramide in Group H<\/jats:styled-content> were the same as those in Group S<\/jats:styled-content>, but Group H + L<\/jats:styled-content> showed a significant increase in the C<\/jats:styled-content>16<\/jats:sub><\/jats:styled-content>:0<\/jats:sub><\/jats:styled-content> component.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The total cardiac ceramide levels are depressed by pressure overload of immature rabbit hearts. Losartan reduced the hypertrophy with selective increase of the relative amount of C<\/jats:styled-content>16:0<\/jats:sub><\/jats:styled-content>\u2010ceramide.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12052","type":"journal-article","created":{"date-parts":[[2013,1,14]],"date-time":"2013-01-14T14:16:25Z","timestamp":1358172985000},"page":"272-276","source":"Crossref","is-referenced-by-count":3,"title":["Modulation of C<\/scp>16:0<\/sub><\/scp>\u2010ceramide in hypertrophied immature hearts by losartan"],"prefix":"10.1111","volume":"55","author":[{"given":"Toshiyuki","family":"Itoi","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiology and Nephrology Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsujiro","family":"Oka","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology and Nephrology Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoto","family":"Terada","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hananoki Medical Welfare Center Kameoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.281.6.H2337"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1999.0934"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(98)01675-5"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.24.16901"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5294.1855"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.72.1359"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)33398-8"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/hh0701.089175"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119360"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1998.275.3.H906"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1074248409356430"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0806529"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200202000-00005"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2008.02.003"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0806529"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.43.30580"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.12052","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.12052","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T18:54:52Z","timestamp":1697309692000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.12052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.1111\/ped.12052"],"URL":"https:\/\/doi.org\/10.1111\/ped.12052","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6]]}}}