{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T07:11:12Z","timestamp":1786950672317,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,6,18]],"date-time":"2013-06-18T00:00:00Z","timestamp":1371513600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2013,6]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Rapid urine\u2010HpAb<\/jats:styled-content> is reported to be a reliable test of H<\/jats:styled-content>elicobacter\u2009pylori<\/jats:italic> infection in adults, but there are no data on the application of the test in children. The aim of this study was to evaluate the accuracy of a urine\u2010based enzyme\u2010linked immunosorbent assay (urine\u2010HpELISA<\/jats:styled-content>) and immunochromatography (rapid urine\u2010HpAb<\/jats:styled-content>) kit for anti\u2010H<\/jats:styled-content>.\u2009pylori<\/jats:italic> immunoglobulin G<\/jats:styled-content> antibody in children. We compared its sensitivity and specificity in reference to the 13<\/jats:sup>C<\/jats:styled-content>\u2010urea\u2010breath test (UBT<\/jats:styled-content>) and H<\/jats:styled-content>.\u2009pylori<\/jats:italic> stool antigen test (HpSA<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>In total, 101 J<\/jats:styled-content>apanese children without significant upper\u2010abdominal symptoms were included (mean age, 7.1 years; range 2\u201315 years). Their sensitivity and specificity were evaluated in reference to the UBT<\/jats:styled-content> and HpSA<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>Thirty\u2010seven children were judged H<\/jats:styled-content>.\u2009pylori<\/jats:italic>\u2010positive and 64 negative by the UBT<\/jats:styled-content> and HpSA<\/jats:styled-content>. No discrepancy in the results was observed between UBT<\/jats:styled-content> and HpSA<\/jats:styled-content>. Urine\u2010HpELISA<\/jats:styled-content> showed 91.9% sensitivity and 96.9% specificity with an accuracy of 95.0%. Rapid urine\u2010HpAb<\/jats:styled-content> showed 78.4% sensitivity and 100% specificity with an accuracy of 92.1%. Seven false negative results for rapid urine\u2010HpAb<\/jats:styled-content> were from children aged younger than 10 years, and their antibody titers of urine\u2010HpELISA<\/jats:styled-content> were lower than true positives.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>For the diagnosis of H<\/jats:styled-content>.\u2009pylori<\/jats:italic> infection in J<\/jats:styled-content>apanese children, both tests are non\u2010invasive, inexpensive, reliable and easy\u2010to\u2010perform methods giving satisfactory accuracy, although the sensitivity of the rapid urine\u2010HpAb<\/jats:styled-content> kit was inferior to that of the urine\u2010HpELISA<\/jats:styled-content> kit, especially in children aged younger than 10 years, showing relatively low titer of H<\/jats:styled-content>.\u2009pylori<\/jats:italic> antibody.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12057","type":"journal-article","created":{"date-parts":[[2013,1,30]],"date-time":"2013-01-30T10:26:39Z","timestamp":1359541599000},"page":"337-341","source":"Crossref","is-referenced-by-count":25,"title":["Diagnostic accuracy of urine\u2010based kits for detection of H<\/scp>elicobacter pylori<\/i> antibody in children"],"prefix":"10.1111","volume":"55","author":[{"given":"Masumi","family":"Okuda","sequence":"first","affiliation":[{"name":"Department of General Medicine and Community Health Science Hyogo College of Medicine Sasayama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Kamiya","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Kyorin University School of Medicine Mitaka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Booka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Wakayama Medical University 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Sasayama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of General Medicine and Community Health Science Hyogo College of Medicine 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