{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T17:11:34Z","timestamp":1758474694245},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,4,16]],"date-time":"2013-04-16T00:00:00Z","timestamp":1366070400000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2013,4]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>During the last decade, new supportive modalities and new therapeutic strategies to treat congenital diaphragmatic hernia (CDH<\/jats:styled-content>) have been introduced. In J<\/jats:styled-content>apan, the large number of hospitals prevents centralizing infants with CDH<\/jats:styled-content> in tertiary centers. The aim of this study was to evaluate the correlations between the number of CDH<\/jats:styled-content> patients, survival rates, and the current strategies employed to treat CDH<\/jats:styled-content> at the individual hospitals.<\/jats:p><\/jats:sec>Methods<\/jats:title>Eighty\u2010three hospitals with 674 CDH<\/jats:styled-content> cases were analyzed using questionnaires. We classified the hospitals into three groups according to the number of CDH<\/jats:styled-content> patients treated: G<\/jats:styled-content>roup 1 (G<\/jats:styled-content>1; more than 21 patients), G<\/jats:styled-content>roup 2 (G<\/jats:styled-content>2; 11\u201320 patients), and G<\/jats:styled-content>roup 3 (G<\/jats:styled-content>3; fewer than 10 patients).<\/jats:p><\/jats:sec>Results<\/jats:title>The median number of CDH<\/jats:styled-content> patients in G<\/jats:styled-content>1, G<\/jats:styled-content>2, and G<\/jats:styled-content>3 were 28, 14, and 4, respectively. The overall survival rate was 74.5%. When only the isolated CDH<\/jats:styled-content> cases with a prenatal diagnosis were included, the overall survival rate was 79.3%. The survival rate of isolated CDH<\/jats:styled-content> cases with a prenatal diagnosis was significantly higher in G<\/jats:styled-content>1 than that in G<\/jats:styled-content>2 or G<\/jats:styled-content>3 (87.2% vs 75.2% vs 74.3%; P<\/jats:italic> < 0.001). There were no differences in perinatal therapeutic strategies among the three groups.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>We concluded that it might therefore be important to centralize infants with CDH<\/jats:styled-content>, especially those with isolated CDH<\/jats:styled-content> with a prenatal diagnosis, to tertiary centers in J<\/jats:styled-content>apan in order to improve the survival rates.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12059","type":"journal-article","created":{"date-parts":[[2013,1,30]],"date-time":"2013-01-30T05:27:28Z","timestamp":1359523648000},"page":"190-196","source":"Crossref","is-referenced-by-count":25,"title":["Effect of hospital volume on the mortality of congenital diaphragmatic hernia in J<\/scp>apan"],"prefix":"10.1111","volume":"55","author":[{"given":"Masahiro","family":"Hayakawa","sequence":"first","affiliation":[{"name":"Center for Maternal\u2010Neonatal Care Nagoya University Hospital Nagoya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miharu","family":"Ito","sequence":"additional","affiliation":[{"name":"Center for Maternal\u2010Neonatal Care Nagoya University Hospital Nagoya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuo","family":"Hattori","sequence":"additional","affiliation":[{"name":"Center for Maternal\u2010Neonatal Care Nagoya University Hospital Nagoya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Kanamori","sequence":"additional","affiliation":[{"name":"Department of General Surgery National Center for Child Health and Development Tokyo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroomi","family":"Okuyama","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Hyogo College of Medicine Nishinomiya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noboru","family":"Inamura","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Osaka Medical Center and Research Institute for Maternal and Child Health Izumi,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigehiro","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Neonatology National Center for Child Health and Development Tokyo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouji","family":"Nagata","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Reproductive and Developmental Medicine, Graduate School of Medical Sciences Kyushu University Fukuoka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoaki","family":"Taguchi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Reproductive and Developmental Medicine, Graduate School of Medical Sciences Kyushu University Fukuoka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriaki","family":"Usui","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Osaka University Graduate School of Medicine Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The Japanese Congenital Diaphragmatic Hernia Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,4,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1099-0496(200009)30:3<249::AID-PPUL9>3.0.CO;2-9"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-008-0904-x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(18)30201-X"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1097\/SLA.0b013e3181f5b538","article-title":"Impact of hospital volume on in\u2010hospital mortality of infants undergoing repair of congenital diaphragmatic hernia","volume":"252","author":"Bucher BT","year":"2010","journal-title":"Ann. 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