{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T05:41:00Z","timestamp":1696052460339},"reference-count":5,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,8,5]],"date-time":"2013-08-05T00:00:00Z","timestamp":1375660800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 2\u2010year\u2010old boy presented with a 21\u2010hydroxylase deficiency, associated with advanced\u2010stage neuroblastoma primarily occurring in the left adrenal gland. He required intensive chemotherapy with polypharmacy, followed by cord blood stem cell transplantation to treat the neuroblastoma. The precise adjustment of cortisol levels was crucial in this patient to prevent adrenal crisis. We administered hydrocortisone by continuous infusion while monitoring blood cortisol levels. As there are no published reports on the target cortisol levels for children, we used two control infants with advanced\u2010stage neuroblastoma, also undergoing chemotherapy and cord blood stem cell transplantation, to guide the continuous hydrocortisone therapy. The daily dose of hydrocortisone during chemotherapy required about threefold the normal treatment to avoid adrenal insufficiency. Continuous hydrocortisone therapy is feasible for preventing adrenal crisis and this report may provide an effective management for hydrocortisone replacement in 21\u2010hydroxylase\u2010deficient patients undergoing chemotherapy and hematopoietic stem cell transplantation.<\/jats:p>","DOI":"10.1111\/ped.12093","type":"journal-article","created":{"date-parts":[[2013,8,5]],"date-time":"2013-08-05T08:19:41Z","timestamp":1375690781000},"source":"Crossref","is-referenced-by-count":0,"title":["Management of advanced\u2010stage neuroblastoma in a patient with 21\u2010hydroxalase deficiency"],"prefix":"10.1111","volume":"55","author":[{"given":"Akari N","family":"Utsunomiya","sequence":"first","affiliation":[{"name":"Department of Pediatrics Hiroshima University Graduate School of Biomedical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hiroshima University Graduate School of Biomedical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Hara","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hiroshima University Graduate School of Biomedical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mizuka","family":"Miki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hiroshima University Graduate School of Biomedical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Mizoguchi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hiroshima University Graduate School of Biomedical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hiroshima University Graduate School of Biomedical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichiro","family":"Miyagawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kure Mutual Hospital  Kure Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Jinno","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hiroshima General Hospital of West Japan Railway Company  Hiroshima"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hiroshima University Graduate School of Biomedical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hiroshima University Graduate School of Biomedical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hiroshima University Graduate School of Biomedical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8,5]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000096420"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.8.6.725"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0181"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.6.14.2407"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2009.22.11.1009"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.12093","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.12093","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T02:07:35Z","timestamp":1696039655000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.12093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":5,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1111\/ped.12093"],"URL":"https:\/\/doi.org\/10.1111\/ped.12093","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8]]}}}