{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:23:50Z","timestamp":1790839430944,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,6,18]],"date-time":"2013-06-18T00:00:00Z","timestamp":1371513600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The aim of the study was to analyze the pre\u2010diagnostic symptomatic interval (\n                      <jats:styled-content style=\"fixed-case\">PSI<\/jats:styled-content>\n                      ) of children with brain tumors with regard to the parental and doctor's delay and the clinical symptoms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective review of all children with brain tumors diagnosed in a single centre over a period of 11 years was carried out.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventy\u2010nine patients (35 boys, 44 girls), with a mean age of 9.2 years (0.2\u201323.5 years), were analyzed.\n                      <jats:styled-content style=\"fixed-case\">PSI<\/jats:styled-content>\n                      was 28 weeks with a parental delay of 11.1 weeks and a doctor's delay of 16.9 weeks. Main clinical symptoms were headache (66.7%), vomiting (57.7%), vision (46.2%) and gait (41.6) disorders and fatigue (41.0%) followed by other neurological signs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Diagnosis of pediatric brain tumors is often delayed in relation to the presenting symptoms. If parents report a combination of headache with other neurological abnormalities, a brain tumor should always be considered.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ped.12095","type":"journal-article","created":{"date-parts":[[2013,3,12]],"date-time":"2013-03-12T23:45:12Z","timestamp":1363131912000},"page":"305-309","source":"Crossref","is-referenced-by-count":30,"title":["Time to diagnosis of brain tumors in children: A single\u2010centre experience"],"prefix":"10.1111","volume":"55","author":[{"given":"Anja","family":"Molineus","sequence":"first","affiliation":[{"name":"Pediatric Oncology Otto\u2010von\u2010Guericke\u2010University Children's Hospital  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Boxberger","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Otto\u2010von\u2010Guericke\u2010University Children's Hospital  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antje","family":"Redlich","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Otto\u2010von\u2010Guericke\u2010University Children's Hospital  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Vorwerk","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Otto\u2010von\u2010Guericke\u2010University Children's Hospital  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,18]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"GurneyJG SmithMA BuninGR.CNS and miscellaneous intracranial and intraspinal neoplasms. SEER Pediatric Monograph. National Cancer Institute2000;51\u201363."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(07)70207-3"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-002-1088-4"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073807308692"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2005.090266"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(07)70212-7"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960815)78:4<874::AID-CNCR26>3.0.CO;2-R"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-008-0755-5"},{"key":"e_1_2_6_10_1","first-page":"115","article-title":"Presenting signs and symptoms of central nervous system tumors according to age","volume":"66","author":"Coserria Sanchez JF","year":"2007","journal-title":"An. Pediatr. (Barc)"},{"key":"e_1_2_6_11_1","first-page":"215","article-title":"Initial signs and symptoms of brain tumors in children","volume":"23","author":"Vazquez RS","year":"2008","journal-title":"Neurologia"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/08880010490263579"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.68.6.771"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.74.2.148"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-200208000-00012"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00112-008-1801-0"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1982.03970380033008"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.067256"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/000992288902800803"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-008-9740-0"},{"key":"e_1_2_6_21_1","first-page":"27","article-title":"Neurologic symptoms as first signs of brain tumor in children","volume":"40","author":"Mucic\u2010Pucic B","year":"2001","journal-title":"Acta Clin. Croat."},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2005.02231.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00112-008-1800-1"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003810050347"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00112-008-1797-5"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/088307380101600216"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.43.5.272"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/104345429501200403"},{"key":"e_1_2_6_29_1","unstructured":"The Brain Tumour Charity. Headsmart2011.http:\/\/www.headsmart.org.uk"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2009.162057"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.12095","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.12095","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T14:55:28Z","timestamp":1697295328000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.12095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.1111\/ped.12095"],"URL":"https:\/\/doi.org\/10.1111\/ped.12095","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6]]}}}