{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T05:41:00Z","timestamp":1696052460752},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,8,5]],"date-time":"2013-08-05T00:00:00Z","timestamp":1375660800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The patient had hepatomegaly with liver dysfunction at the age of 1 month. Magnetic resonance imaging performed at the age of 1 year showed multiple nodules of varying size in his liver. We were able to examine the mitochondrial respiratory chain function in the liver biopsy samples because all other differential diagnoses for hepatic cirrhosis had been ruled out. Complex <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> activities were below the normal level (&lt;30%) of the citrate synthase (CS) ratio. Liver blue native polyacrylamide gel electrophoresis showed an extremely weak complex <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> band. Liver respiratory chain complexes <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> were found to be deficient in this patient. The histologic findings were highly suggestive of mitochondrial respiratory chain disorder. Findings of progressive liver cirrhosis changes were observed in magnetic resonance imaging at the age of 5 years. An examination of the mitochondrial respiratory chain function should be performed along with a liver biopsy if mitochondrial respiratory chain disorder is suspected as a possible differential diagnosis of idiopathic hepatitis.<\/jats:p>","DOI":"10.1111\/ped.12098","type":"journal-article","created":{"date-parts":[[2013,8,5]],"date-time":"2013-08-05T08:19:41Z","timestamp":1375690781000},"source":"Crossref","is-referenced-by-count":0,"title":["Case of an infant with hepatic cirrhosis caused by mitochondrial respiratory chain disorder"],"prefix":"10.1111","volume":"55","author":[{"given":"Shigehiro","family":"Enkai","sequence":"first","affiliation":[{"name":"Department of Pediatrics Fussa Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachi","family":"Koinuma","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology National Center for Child Health and Development"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reiko","family":"Ito","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology National Center for Child Health and Development"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko","family":"Igaki","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism Tokyo Metropolitan Children's Medical Center  Tokyo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiro","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism Tokyo Metropolitan Children's Medical Center  Tokyo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Murayama","sequence":"additional","affiliation":[{"name":"Division of Metabolism Chiba Children's Hospital  Chiba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Ohtake","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Saitama Medical University  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8,5]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2006.05.036"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21710"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(88)90179-0"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000033795.17156.00"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.6.1255"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2011.05.002"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511547409"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.241035050"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.283055108"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.10.023"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.12098","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.12098","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T02:07:36Z","timestamp":1696039656000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.12098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1111\/ped.12098"],"URL":"https:\/\/doi.org\/10.1111\/ped.12098","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8]]}}}