{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T03:40:32Z","timestamp":1769571632740,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,6,10]],"date-time":"2013-06-10T00:00:00Z","timestamp":1370822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Several studies have suggested that i.v. atropine has a potential role in treating infantile hypertrophic pyloric stenosis (<jats:styled-content style=\"fixed-case\">IHPS<\/jats:styled-content>). It remains unclear, however, whether surgery can be replaced by i.v. therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were extracted on infants with <jats:styled-content style=\"fixed-case\">IHPS<\/jats:styled-content> who were treated with atropine and\/or surgery, from a nationwide administrative database through 2006\u20132008. Patient demographic data, treatment effects and length of hospital stay were analyzed in each treatment group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 585 infants met the criteria for <jats:styled-content style=\"fixed-case\">IHPS<\/jats:styled-content>; 188 patients (32%) were initially treated with atropine (<jats:styled-content style=\"fixed-case\">i.v.<\/jats:styled-content> form, <jats:italic>n<\/jats:italic> = 180; oral form, <jats:italic>n<\/jats:italic> = 8), while 397 were treated with surgery as a first\u2010line therapy. Of the 180 infants receiving <jats:styled-content style=\"fixed-case\">i.v.<\/jats:styled-content> atropine, 38 were withdrawn from medical management and subsequently underwent surgery. Thus, the overall success rate of <jats:styled-content style=\"fixed-case\">i.v.<\/jats:styled-content> atropine was 78.9% (142\/180). Surgery had a success rate of 100%, and postoperative complications were found in 2.8% of patients (12\/435). Medical management required longer hospital stay than surgery (mean, 13.5 days vs 8.0 days; <jats:italic>P<\/jats:italic> &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Surgery remains the suitable standard management option for <jats:styled-content style=\"fixed-case\">IHPS<\/jats:styled-content>, with its high success rate, minimal complications and shorter hospital stay compared with <jats:styled-content style=\"fixed-case\">i.v.<\/jats:styled-content> atropine therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12100","type":"journal-article","created":{"date-parts":[[2013,3,15]],"date-time":"2013-03-15T18:44:04Z","timestamp":1363373044000},"page":"488-491","source":"Crossref","is-referenced-by-count":20,"title":["Pyloromyotomy versus i.v. atropine therapy for the treatment of infantile pyloric stenosis: Nationwide hospital discharge database analysis"],"prefix":"10.1111","volume":"55","author":[{"given":"Masato","family":"Takeuchi","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Tokyo Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Yasunaga","sequence":"additional","affiliation":[{"name":"Department of Health Management and Policy Graduate School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromasa","family":"Horiguchi","sequence":"additional","affiliation":[{"name":"Department of Health Management and Policy Graduate School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Health Economics and Epidemiology Research School of Public Health, University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Community Health University of Occupational and Environmental Health  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2006.10.004"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-02842-4.50079-6"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2272011329"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-006-1751-3"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199608000-00013"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2005.08.025"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-7-50"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healthpol.2007.07.015"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.156.7.647"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2005.03.011"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2009.02.067"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003830050480"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2001.27939"},{"key":"e_1_2_6_15_1","first-page":"136","article-title":"Medical treatment with atropine sulfate for hypertrophic pyloric stenosis","volume":"45","author":"Huang YC","year":"2004","journal-title":"Acta Paediatr. 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