{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T05:50:27Z","timestamp":1771307427156,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,7,30]],"date-time":"2013-07-30T00:00:00Z","timestamp":1375142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to compare two neuroprotective strategies to supportive care in the treatment of perinatal asphyxia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 67 term newborns with perinatal asphyxia were included and randomized into three groups: one group received supportive treatment; another group received a single dose of 40\u2009mg\/kg phenobarbital; and the third received three daily doses of 1000\u2009<jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\/kg erythropoietin. The following parameters were analyzed: gestational age, birthweight, Apgar scores, cord blood <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>, total serum antioxidant status (<jats:styled-content style=\"fixed-case\">TAS<\/jats:styled-content>), superoxide dismutase (<jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content>), glutathione peroxidase (<jats:styled-content style=\"fixed-case\">GPx<\/jats:styled-content>) and malondialdehyde (<jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content>). The newborns were included in the follow\u2010up program and examined up to 18 months of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">TAS<\/jats:styled-content> was higher in the erythropoietin group than in the other groups. <jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">GPx<\/jats:styled-content> were lower for infants treated with phenobarbital or erythropoietin compared to control infants. <jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content> was lower in the erythropoietin group compared to the other groups, although the difference was not statistically significant (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic> &gt; 0.05). The mortality rate was lower in the phenobarbital and erythropoietin groups (both 4.6%) than in the control group (17.4%). Long\u2010term neurologic follow up showed a high incidence of sequelae in the control group compared to the phenobarbital and erythropoietin groups. Follow\u2010up results were better in the phenobarbital group than in the erythropoietin group for motor and cognitive function at 3 and 6 months and worse for expressive language. At 18 months, however, the differences between these two groups were not significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High\u2010dose phenobarbital or erythropoietin along with supportive treatment has a positive influence on the outcome of newborns with perinatal asphyxia. Phenobarbital has the advantage of low cost and simplicity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12121","type":"journal-article","created":{"date-parts":[[2013,5,10]],"date-time":"2013-05-10T10:52:17Z","timestamp":1368183137000},"page":"589-593","source":"Crossref","is-referenced-by-count":30,"title":["High\u2010dose phenobarbital or erythropoietin for the treatment of perinatal asphyxia in term newborns"],"prefix":"10.1111","volume":"55","author":[{"given":"Andreea","family":"Avasiloaiei","sequence":"first","affiliation":[{"name":"Department of Mother and Child Care Gr.T.Popa University of Medicine and Pharmacy  Iasi Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Dimitriu","sequence":"additional","affiliation":[{"name":"Department of Fundamental Sciences Gr.T.Popa University of Medicine and Pharmacy  Iasi Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihaela","family":"Moscalu","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Sciences Gr.T.Popa University of Medicine and Pharmacy  Iasi Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luminita","family":"Paduraru","sequence":"additional","affiliation":[{"name":"Department of Mother and Child Care Gr.T.Popa University of Medicine and Pharmacy  Iasi Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Stamatin","sequence":"additional","affiliation":[{"name":"Department of Mother and Child Care Gr.T.Popa University of Medicine and Pharmacy  Iasi Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,7,30]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Neurological and Neuromuscular Disorders in Avery's Pathophysiology and Management of the Newborn","author":"Hill A","year":"2005"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.1992.tb00697.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1992.tb10990.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2003.91"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(96)00000-8"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9120(99)00075-2"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.201.8.1203"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcps050929"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)17946-X"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0900854"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpediatrics.2011.43"},{"key":"e_1_2_6_13_1","first-page":"e1","article-title":"Effect of high\u2010dose phenobarbital on oxidative stress in perinatal asphyxia: An open label randomized controlled trial","volume":"47","author":"Gathwala G","year":"2010","journal-title":"Indian Pediatr."},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-2268"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e328336eb57"},{"key":"e_1_2_6_16_1","volume-title":"Neonatal Encephalopathy and Cerebral Palsy: Defining the Pathogenesis and Pathophysiology","author":"American College of Obstetrics and Gynecology, Task Force on Neonatal Encephalopathy and Cerebral Palsy; American Academy of Pediatrics","year":"2003"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(85)90381-9"},{"key":"e_1_2_6_18_1","first-page":"158","article-title":"Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase","volume":"70","author":"Paglia DE","year":"1967","journal-title":"J. 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