{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T07:52:26Z","timestamp":1771660346831,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,7,30]],"date-time":"2013-07-30T00:00:00Z","timestamp":1375142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2013,10]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Congenital cytomegalovirus (CMV<\/jats:styled-content>) infection and neonatal herpes are major mother\u2010to\u2010child infections, and analyses of the important clinical issues, including risk factors for prognosis, are essential.<\/jats:p><\/jats:sec>Methods<\/jats:title>A secondary survey of congenital CMV<\/jats:styled-content> infection and neonatal herpes was performed using questionnaires for cases reported in the primary survey between 2006 and 2008.<\/jats:p><\/jats:sec>Results<\/jats:title>Univariate analysis of 71 cases of congenital CMV<\/jats:styled-content> infection showed that intrauterine growth restriction (IUGR<\/jats:styled-content>) or other specific findings on fetal ultrasonography (US<\/jats:styled-content>), microcephaly, intracranial calcification, disseminated intravascular coagulation, abnormal findings on computed tomography, and the use of i.v. gammaglobulin were all significantly correlated with poor outcome (death or severe sequelae). Multivariate analysis showed that only IUGR<\/jats:styled-content> was significantly associated with poor outcome. Hearing impairment is one of the major abnormalities associated with congenital CMV<\/jats:styled-content> infection. Automatic auditory brainstem response (automatic ABR<\/jats:styled-content>) appeared to be useful for detection of hearing impairment in comparison with conventional ABR<\/jats:styled-content>. Moreover, univariate analysis showed that specific fetal US<\/jats:styled-content> or abnormal magnetic resonance imaging findings were correlated with sensorineural hearing loss. In 24 cases of neonatal herpes, fever and seizure were correlated with poor outcome on univariate analysis. All patients received acyclovir treatment, although substantial numbers of patients in severe clinical categories (disseminated or central nervous system diseases) received a low dose of acyclovir (<60\u2009mg\/kg per day).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>This secondary survey has identified the risk factors associated with outcome and important issues in diagnosis and treatment of two mother\u2010to\u2010child infections: congenital CMV<\/jats:styled-content> and neonatal herpes, in J<\/jats:styled-content>apan.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12122","type":"journal-article","created":{"date-parts":[[2013,5,10]],"date-time":"2013-05-10T10:52:17Z","timestamp":1368183137000},"page":"566-571","source":"Crossref","is-referenced-by-count":19,"title":["Risk factors for poor outcome in congenital cytomegalovirus infection and neonatal herpes on the basis of a nationwide survey in J<\/scp>apan"],"prefix":"10.1111","volume":"55","author":[{"given":"Yoshinori","family":"Ito","sequence":"first","affiliation":[{"name":"Department of Pediatrics Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Virology Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Torii","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Hayakawa","sequence":"additional","affiliation":[{"name":"Center for Maternal\u2010Neonatal Care Nagoya University Hospital Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiro","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shizuoka Kosei Hospital Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Tajiri","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Osaka General Medical Center Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Yoto","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Sapporo Medical University School of Medicine Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Tanaka\u2010Taya","sequence":"additional","affiliation":[{"name":"Infectious Disease Surveillance Center National Institute of Infectious Diseases Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirokazu","family":"Kanegane","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Graduate School of Medicine and Pharmaceutical Science University of Toyama Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiyoshi","family":"Nariai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Yokohama Minami Kyosai Hospital Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Sakata","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Asahikawa Kosei Hospital Asahikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Tsutsumi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Sapporo Medical University School of Medicine Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megumi","family":"Oda","sequence":"additional","affiliation":[{"name":"Graduate Schools of Health Sciences and Department of Pediatric Hematology\/Oncology Okayama University Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shumpei","family":"Yokota","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Yokohama City University School of Medicine Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuneo","family":"Morishima","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Graduate School of Medicine and Dentistry Okayama University Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Moriuchi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Graduate School of Biomedical Sciences Nagasaki University Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Japanese Society for Pediatric Infectious Diseases","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,7,30]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"300","volume-title":"Red Book: 2012 Report of the Committee on Infectious Diseases","author":"Committee on Infectious Diseases, American Academy of Pediatrics","year":"2012"},{"key":"e_1_2_6_3_1","first-page":"398","volume-title":"Red Book: 2012 Report of the Committee on Infectious Diseases","author":"Committee on Infectious Diseases, American Academy of Pediatrics","year":"2012"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3182897c36"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2005.09.015"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1986.03380140074025"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/20.3.665"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2007.10.015"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043337"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir718"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(03)00192-6"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/528376"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2009.08.012"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.03.002"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2011-000118"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1006561"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.2.230"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.12122","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.12122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T23:12:21Z","timestamp":1696201941000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.12122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,30]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1111\/ped.12122"],"URL":"https:\/\/doi.org\/10.1111\/ped.12122","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,30]]}}}