{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:28:09Z","timestamp":1761895689446},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,7,30]],"date-time":"2013-07-30T00:00:00Z","timestamp":1375142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2013,10]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The aim of this study was to evaluate the treatment outcomes of intravitreal bevacizumab (IVB<\/jats:styled-content>) injections, used as a monotherapy in type 1 retinopathy of prematurity (ROP<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>A retrospective chart review was performed for 17 type 1 ROP<\/jats:styled-content> patients (34 eyes), who had IVB<\/jats:styled-content> injection between J<\/jats:styled-content>uly 2011 and J<\/jats:styled-content>une 2012. Birthweight, gestational age at birth, stage and location of ROP<\/jats:styled-content>, IVB<\/jats:styled-content> injection time, time of complete retinal vascularization, and additional treatments if needed, were noted. A total of 0.625\u2009mg (0.025\u2009mL) bevacizumab was injected intravitreally.<\/jats:p><\/jats:sec>Results<\/jats:title>Thirty eyes of 17 patients with type 1 ROP<\/jats:styled-content> enrolled in the study were treated with IVB<\/jats:styled-content> injection. Of them seven had aggressive posterior\u2010ROP<\/jats:styled-content>, six had stage 2 ROP<\/jats:styled-content>, and four had stage 3 ROP<\/jats:styled-content>. The mean gestational age was 28.44 weeks (range, 26\u201331 weeks); and the mean birthweight was 1151.88\u2009g (range, 600\u20131600\u2009g). The mean age for IVB<\/jats:styled-content> injection was 35.47 weeks. The mean full retinal vascularization time was 136.6 \u00b1 26.6 days. The mean follow\u2010up time was 285.3 \u00b1 70 days. ROP<\/jats:styled-content> was regressed and retinal vascularization was completed in all cases except one eye, which had threshold disease.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>IVB<\/jats:styled-content> injection, used as a monotherapy, is an effective treatment approach in patients with type 1 ROP<\/jats:styled-content>. Timely treatment of stage 2 and early stage 3 ROP<\/jats:styled-content> in which disease progression was observed, prevents vitreoretinal membrane formation in posterior disease. Further studies need to be performed to determine the safety of IVB<\/jats:styled-content> injection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12124","type":"journal-article","created":{"date-parts":[[2013,5,10]],"date-time":"2013-05-10T10:52:32Z","timestamp":1368183152000},"page":"599-603","source":"Crossref","is-referenced-by-count":20,"title":["Intravitreal bevacizumab monotherapy for retinopathy of prematurity"],"prefix":"10.1111","volume":"55","author":[{"given":"Alparslan","family":"\u015eahin","sequence":"first","affiliation":[{"name":"Department of Ophthalmology School of Medicine Dicle University Diyarbak\u0131r Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammed","family":"\u015eahin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology School of Medicine Dicle University Diyarbak\u0131r Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah 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