{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:21:54Z","timestamp":1761153714890},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,7,30]],"date-time":"2013-07-30T00:00:00Z","timestamp":1375142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2013,10]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The predictive factors of negative outcome in initial i.v. atropine (IA<\/jats:styled-content>) therapy of infantile hypertrophic pyloric stenosis (IHPS<\/jats:styled-content>) are unknown. Conservative therapy for IHPS<\/jats:styled-content> is useful for infants because it does not have the risk of surgical and anesthetic stress, but some cases of atropine therapy result in failure. This study clarified the predictive markers of negative outcome in initial atropine therapy for IHPS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Seventy\u2010six patients with IHPS<\/jats:styled-content> admitted from 1998 to 2011 were included in this study. The predictive risk factors of negative outcome in initial atropine therapy for IHPS<\/jats:styled-content> were evaluated.<\/jats:p><\/jats:sec>Results<\/jats:title>Thirty\u2010one patients initially underwent non\u2010operative therapy for IHPS<\/jats:styled-content> during the study period. Of the 31 patients, 18 (58%) ceased projectile vomiting (PV) with IA and subsequent oral atropine. Univariate analysis showed that lack of bodyweight gain before treatment, elevated urine potassium at admission, and PV occurring \u22655 times (PV<\/jats:styled-content> \u22655) in total for 3 days from IA<\/jats:styled-content> initiation were predictive risk factors for negative outcome in IHPS<\/jats:styled-content>. Multivariate analysis identified only PV<\/jats:styled-content> \u22655 in total for 3 days after IA<\/jats:styled-content> initiation as independently associated with failure of atropine for IHPS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>PV<\/jats:styled-content> \u22655 in total for 3 days after IA<\/jats:styled-content> initiation is a potential indicator of negative outcome of IA in IHPS<\/jats:styled-content> patients. The present results provide valuable information for determining whether early surgical intervention for IHPS<\/jats:styled-content> or initial atropine therapy is the best option.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12137","type":"journal-article","created":{"date-parts":[[2013,5,23]],"date-time":"2013-05-23T14:56:25Z","timestamp":1369320985000},"page":"619-623","source":"Crossref","is-referenced-by-count":10,"title":["Predictive factors of negative outcome in initial atropine therapy for infantile hypertrophic pyloric stenosis"],"prefix":"10.1111","volume":"55","author":[{"given":"Yuhki","family":"Koike","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery National Mie Hospital Mie Japan"},{"name":"Department of Gastrointestinal and Pediatric Surgery Division of Reparative Medicine Institute of Life Sciences Mie University Graduate School of Medicine Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Pediatric Surgery Division of Reparative Medicine Institute of Life Sciences Mie University Graduate School of Medicine Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Nakazawa","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery National Mie Hospital Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikihiro","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Pediatric Surgery Division of Reparative Medicine Institute of Life Sciences Mie University Graduate School of Medicine Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Kusunoki","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Pediatric Surgery Division of Reparative Medicine Institute of Life Sciences Mie University Graduate School of Medicine Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihide","family":"Tsukamoto","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery National Mie Hospital Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,7,30]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2272011329"},{"key":"e_1_2_5_3_1","first-page":"467","volume-title":"Principles of Pediatric Surgery","author":"O'Neill JA","year":"2004"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(87)80599-7"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(62)91128-5"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-006-1751-3"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2005.08.025"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(97)00075-5"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(96)90172-4"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.87.1.71"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(00)90036-8"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199608000-00013"},{"key":"e_1_2_5_13_1","first-page":"136","article-title":"Medical treatment with atropine sulfate for hypertrophic pyloric stenosis","volume":"45","author":"Huang YC","year":"2004","journal-title":"Acta Paediatr. 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