{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:21:55Z","timestamp":1761765715367},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,10,18]],"date-time":"2013-10-18T00:00:00Z","timestamp":1382054400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic><jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>treptococcus pyogenes<\/jats:italic> is the most common cause of post\u2010infectious glomerulonephritis. Described herein is the case of a 5\u2010year\u2010old girl with febrile post\u2010streptococcal acute glomerulonephritis (<jats:styled-content style=\"fixed-case\">PSAGN<\/jats:styled-content>) associated with pneumococcal bacteremia. The chief complaints were fever and macrohematuria without respiratory symptoms. Urinalysis indicated a protein level of 3+. Serological data showed elevated anti\u2010streptolysin <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">ASO<\/jats:styled-content>) and hypocomplementemia. Blood culture was positive for <jats:italic><jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>.\u2009pneumoniae<\/jats:italic>. Her acute renal failure was mild and improved over several days. Although <jats:styled-content style=\"fixed-case\">PSAGN<\/jats:styled-content> was confirmed by elevated <jats:styled-content style=\"fixed-case\">ASO<\/jats:styled-content> and transient hypocomplementemia, the clinical course was consistent with those of several reported cases of <jats:styled-content style=\"fixed-case\">AGN<\/jats:styled-content> associated with pneumococcal infection. To our knowledge, there have been few reports on the relationship between pneumococcal infection and the incidence of <jats:styled-content style=\"fixed-case\">PSAGN<\/jats:styled-content>. We suggest the hypothesis that pneumococcal infection itself could exaggerate the complement reaction leading to <jats:styled-content style=\"fixed-case\">PSAGN<\/jats:styled-content>. It is important to consider <jats:styled-content style=\"fixed-case\">PSAGN<\/jats:styled-content> associated with a microbial infection such as <jats:italic><jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>.\u2009pneumoniae<\/jats:italic> when faced with a febrile patient with <jats:styled-content style=\"fixed-case\">AGN<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/ped.12150","type":"journal-article","created":{"date-parts":[[2013,10,18]],"date-time":"2013-10-18T08:11:41Z","timestamp":1382083901000},"source":"Crossref","is-referenced-by-count":4,"title":["Post\u2010streptococcal acute glomerulonephritis associated with pneumococcal infection"],"prefix":"10.1111","volume":"55","author":[{"given":"Satoshi","family":"Hibino","sequence":"first","affiliation":[{"name":"Department of Pediatrics Showa University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Hoshino","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Showa University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanari","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Showa University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshifusa","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Showa University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuichiro","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Watanabe Children's Clinic  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Uemura","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology Aichi Children's Health and Medical Center  Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Itabashi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Showa University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,18]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(75)90636-1"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-005-1994-6"},{"key":"e_1_2_4_4_1","first-page":"211","article-title":"Acute glomerulonephritis secondary to lobar pneumonia","volume":"8","author":"Schachter J","year":"1987","journal-title":"Int. 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