{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T16:31:02Z","timestamp":1745857862816},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,8,21]],"date-time":"2013-08-21T00:00:00Z","timestamp":1377043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The major pathogenic factors involved in nocturnal enuresis are nocturnal polyuria, small bladder capacity and\/or detrusor overactivity, and a high arousal threshold. Desmopressin is the first\u2010line therapy for the patients with diuresis\u2010dependent nocturnal enuresis. <jats:italic><jats:styled-content style=\"fixed-case\">Y<\/jats:styled-content>okukansan<\/jats:italic>, a traditional Japanese medicine, has been used in <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apan to treat patients with nervousness, insomnia, and children with night terrors and temper tantrums. We experienced the positive effect of <jats:italic><jats:styled-content style=\"fixed-case\">Y<\/jats:styled-content>okukansan<\/jats:italic> in some of the patients who did not respond well to desmopressin therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 32 children with monosymptomatic nocturnal enuresis with nocturnal polyuria were treated with oral desmopressin melt tablets, which were approved for clinical use in <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apan on 29 <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ay 2012. This treatment was effective for 14 of them. For the rest (<jats:italic>n<\/jats:italic> = 18), <jats:italic>Yokukansan<\/jats:italic> was introduced in combination with desmopressin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic><jats:styled-content style=\"fixed-case\">Y<\/jats:styled-content>okukansan<\/jats:italic> was effective for 12 out of the 18 cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:\u2002<\/jats:title><jats:p><jats:italic>Yokukansan<\/jats:italic> should be a candidate for the medication of nocturnal enuresis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12158","type":"journal-article","created":{"date-parts":[[2013,6,17]],"date-time":"2013-06-17T10:25:59Z","timestamp":1371464759000},"page":"737-740","source":"Crossref","is-referenced-by-count":9,"title":["Traditional <scp>J<\/scp>apanese medicine, <i><scp>Y<\/scp>okukansan<\/i>, for the treatment of nocturnal enuresis in children"],"prefix":"10.1111","volume":"55","author":[{"given":"Yoshiyuki","family":"Ohtomo","sequence":"first","affiliation":[{"name":"Department of Pediatrics Juntendo University Nerima Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Umino","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Juntendo University Nerima Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Takada","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Musashi Murayama Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Niijima","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Juntendo University Nerima Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuichiro","family":"Fujinaga","sequence":"additional","affiliation":[{"name":"Division of Nephrology Saitama Children's Medical Center  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiaki","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Juntendo University Graduate School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(06)00305-3"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000111504.85822.b2"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2006.10.093"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-012-1687-7"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.10.043"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-011-1762-8"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1999.tb00036.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1997.tb09027.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/953459"},{"key":"e_1_2_5_11_1","first-page":"20","article-title":"Urodynamics in normal infants and children","volume":"114","author":"Hjalmas K","year":"1998","journal-title":"Scand. 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