{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T22:38:22Z","timestamp":1772491102585,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,9,20]],"date-time":"2013-09-20T00:00:00Z","timestamp":1379635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Lactobezoar is a compact mass of inspissated, undigested milk. Most often it is located in the stomach but it may also be located in other parts of the intestine. It is the most common type of bezoar in infancy. Reported herein are two cases of this rare condition mimicking necrotizing enterocolitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Data on two complicated cases of lactobezoar were retrospective analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The first case involved a female infant, born at 37 weeks 2 days gestation with a birthweight of 3050\u2009g, and multiple antenatal known congenital defects. Due to esophageal atresia she was given a gastrostomy on the second day of life. After 20 days of continuous feeding with formula feeding she developed food intolerance and clinical signs of a severe sepsis. On examination the abdomen was severely distended and tender at palpation. No palpable mass was noted at examination. Signs of hemodynamic instability and sepsis evolved. Plain abdominal <jats:styled-content style=\"fixed-case\">X<\/jats:styled-content>\u2010ray showed a pneumatosis of the stomach matching necrotizing enterocolitis (<jats:styled-content style=\"fixed-case\">NEC<\/jats:styled-content>). During emergency laparotomy a gastric bezoar was seen and removed. The postoperative course was complicated by prolonged motility disturbance of the stomach. For a long time she was fed through a jejunostomy. The second case involved a female infant born at 26 weeks 4 days (birthweight 1040\u2009g) who became progressively septic on the day 6 of life. On examination she had a tender and distended abdomen, and abdominal <jats:styled-content style=\"fixed-case\">X<\/jats:styled-content>\u2010ray showed intra\u2010abdominal air, consistent with a gastrointestinal perforation. On emergency laparotomy a perforation was seen at the back of the stomach, due to a lactobezoar, with only a little necrosis surrounding it. Surgical treatment consisted of extraction of the lactobezoar and closure of the perforation at the back of the stomach. Two days after the initial surgery, she developed a leakage of the suture anastomosis and another laparotomy was performed. A drain was left near the stomach. After 2 weeks she recovered quickly and feeding was initiated at day 21 with good outcome after 3 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Factors associated with the development of lactobezoar are prematurity, low birthweight, disturbed gastric emptying, hypercaloric and hyperosmolaric milk compositions. It is important to realize that lactobezoar formation can occur in preterm and full\u2010term infants, receiving either breast milk or formula, even when only minimal enteral feeding is given. Early recognition and treatment of this condition is critical. If a lactobezoar is not detected in an early phase, patients can deteriorate very quickly into a condition mimicking <jats:styled-content style=\"fixed-case\">NEC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12164","type":"journal-article","created":{"date-parts":[[2013,6,24]],"date-time":"2013-06-24T03:28:05Z","timestamp":1372044485000},"page":"757-760","source":"Crossref","is-referenced-by-count":20,"title":["Gastric pneumatosis and rupture caused by lactobezoar"],"prefix":"10.1111","volume":"55","author":[{"given":"Marthel E.","family":"Bos","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery Erasmus MC\u2010Sophia Children's Hospital  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rene M. H.","family":"Wijnen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Erasmus MC\u2010Sophia Children's Hospital  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivo","family":"de Blaauw","sequence":"additional","affiliation":[{"name":"Department of Surgery\u2010Pediatric Surgery Radboud University Nijmegen Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,9,20]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.5402\/2012\/562594"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2012.04.001"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(59)80150-5"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006565-198809000-00009"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.55.2.128"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(70)80252-9"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-7-3"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006565-199708000-00007"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01314940"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-003-0968-7"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000087631"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/000992280104001104"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr.03.2009.1708"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2006.03.034"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2010.195388"},{"key":"e_1_2_4_17_1","first-page":"895","article-title":"Lactobezoar and necrotizing enterocolitis in a preterm infant","volume":"5","author":"Mandel D","year":"2003","journal-title":"Isr. 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