{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:28:15Z","timestamp":1760984895085},"reference-count":11,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,12,11]],"date-time":"2013-12-11T00:00:00Z","timestamp":1386720000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hemolytic uremic syndrome (<jats:styled-content style=\"fixed-case\">HUS<\/jats:styled-content>) in children is usually caused by <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>higa\u2010like toxin\u2010producing <jats:italic><jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>scherichia coli<\/jats:italic>, but approximately 5% of cases are caused by invasive pneumococcal infection (<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HUS<\/jats:styled-content>). Reported herein is the case of a 9\u2010month\u2010old <jats:styled-content style=\"fixed-case\">HUS<\/jats:styled-content> patient with pneumococcal meningitis who needed hemodialysis for 12 days. Decreased sialylation was characterized in both transferrin <jats:italic><jats:styled-content style=\"fixed-case\">N<\/jats:styled-content><\/jats:italic>\u2010glycans and <jats:styled-content style=\"fixed-case\">IgA1<\/jats:styled-content>\u2005<jats:italic><jats:styled-content style=\"fixed-case\">O<\/jats:styled-content><\/jats:italic>\u2010glycans, analyzed in the acute phase on mass spectrometry, consistent with <jats:italic><jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>.\u2009pneumonia<\/jats:italic>\u2010produced sialidases hydrolyzing both \u03b12,3\u2010 and \u03b12,6\u2010linked sialic acids. The method will complement the <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010antigen activation test and help to understand the molecular pathology related to <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HUS<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/ped.12166","type":"journal-article","created":{"date-parts":[[2013,12,12]],"date-time":"2013-12-12T02:15:13Z","timestamp":1386814513000},"source":"Crossref","is-referenced-by-count":4,"title":["Decreased sialylation of <scp>IgA1<\/scp>\u2005<i><scp>O<\/scp><\/i>\u2010glycans associated with pneumococcal hemolytic uremic syndrome"],"prefix":"10.1111","volume":"55","author":[{"given":"Hisaaki","family":"Aoki","sequence":"first","affiliation":[{"name":"Pediatric Department Sakai Municipal Hospital  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Shiomi","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Osaka City General Hospital  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Pediatric Department Sakai Municipal Hospital  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsubura","family":"Ishii","sequence":"additional","affiliation":[{"name":"Pediatric Department Sakai Municipal Hospital  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhiko","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Pediatric Department Sakai Municipal Hospital  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Togawa","sequence":"additional","affiliation":[{"name":"Department of Pediatric Emergency Medicine Osaka City General Hospital  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhiko","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Osaka Medical Center and Research Institute for Maternal and Child Health  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Machiko","family":"Kadoya","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine Osaka Medical Center and Research Institute for Maternal and Child Health  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinao","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine Osaka Medical Center and Research Institute for Maternal and Child Health  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12,11]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)92915-4"},{"key":"e_1_2_5_3_1","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1093\/clinchem\/48.5.781","article-title":"Hemolytic uremic syndrome attributable to Streptococcus pneumoniae infection: A novel cause for secondary protein N\u2010glycan abnormalities","volume":"48","author":"Loos F","year":"2002","journal-title":"Clin. 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