{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T12:59:51Z","timestamp":1715950791819},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,9,20]],"date-time":"2013-09-20T00:00:00Z","timestamp":1379635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to evaluate the factors predicting the response to allergen\u2010specific immunotherapy (<jats:styled-content style=\"fixed-case\">ASIT<\/jats:styled-content>) in children with asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The case notes of children with asthma who received <jats:styled-content style=\"fixed-case\">ASIT<\/jats:styled-content> for 2 years were retrospectively reviewed. The cases were then divided into an effective clinical response group, defined as absence of asthma symptoms without requirement for medication for at least 6 months during follow up; and an ineffective clinical response group. At the time of initiating treatment, blood was collected for analysis of serum total <jats:styled-content style=\"fixed-case\">IgE<\/jats:styled-content>. Family history of atopy, history of passive smoking, onset age of wheezing and so on was obtained from each patient. Ten factors that may influence children's response were analyzed on logistic regression analysis and compared between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 99 children with asthma received <jats:styled-content style=\"fixed-case\">ASIT<\/jats:styled-content> s.c. for 2 years during <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>eptember 2007\u2013<jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ebruary 2010. The average age was 8.66 \u00b1 0.30 years. Good response to <jats:styled-content style=\"fixed-case\">ASIT<\/jats:styled-content> was found in 72 cases, while an inadequate response was found in 27 cases. Of the 10 factors tested for correlation with clinical response to <jats:styled-content style=\"fixed-case\">ASIT<\/jats:styled-content>, a significant correlation was found with onset age of wheezing and airway hyperresponsiveness (<jats:styled-content style=\"fixed-case\">AHR<\/jats:styled-content>). The odds ratio for the onset age of wheezing was 2.81 (95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>]: 1.40\u20135.65, <jats:italic>P<\/jats:italic> = 0.004) and that for <jats:styled-content style=\"fixed-case\">AHR<\/jats:styled-content> was 1.33 (95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.04\u20131.70, <jats:italic>P<\/jats:italic> = 0.021).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Potential predictors for the response to <jats:styled-content style=\"fixed-case\">ASIT<\/jats:styled-content> in children with asthma were identified. Onset age of wheezing and <jats:styled-content style=\"fixed-case\">AHR<\/jats:styled-content> may influence response to <jats:styled-content style=\"fixed-case\">ASIT<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12175","type":"journal-article","created":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T02:14:03Z","timestamp":1372644843000},"page":"680-684","source":"Crossref","is-referenced-by-count":2,"title":["Factors influencing the response to specific immunotherapy for asthma in children aged 5\u201316 years"],"prefix":"10.1111","volume":"55","author":[{"given":"Wansheng","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Pediatrics First Affiliation Hospital of Bengbu Medical College  Bengbu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enmei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Children's Hospital Chongqing Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,9,20]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"6","article-title":"Allergen immunotherapy: Therapeutic vaccines for allergic diseases","volume":"44","author":"WHO Position Paper","year":"1998","journal-title":"J. Allergy"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01620.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.08.024"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60103-2"},{"key":"e_1_2_6_6_1","first-page":"29","article-title":"Meta\u2010analysis of sublingual immunotherapy with mite allergen for children asthma","volume":"4","author":"Peng WS","year":"2009","journal-title":"Chin. J. Evid. Based Pediatr."},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02631.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(93)90190-Q"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199701303360502"},{"key":"e_1_2_6_10_1","volume-title":"Global Strategy for Asthma Management and Prevention: NHLBI\/WHO Workshop Report","author":"Global Initiative for Asthma (GINA)","year":"2006"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.02.012"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2001.056005359.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01312.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2004.00654.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60755-7"},{"key":"e_1_2_6_16_1","first-page":"694094","article-title":"Can serum specific IgE\/total IgE ratio predict clinical response to allergen specific immunotherapy in children monosensitized to house dust mite?","volume":"2012","author":"Karakoc GB","year":"2012","journal-title":"J. Allergy (Cairo)"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.10.041"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.07.056"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2002.23504.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.1595"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60826-5"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2004.09.011"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052632"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.121.6.1782"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199501193320301"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-009-0065-7"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.36.9.614"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(86)90226-5"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00112606"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.2174\/138945006776818728"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.129429"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00023608"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.07.012"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.supplement_1.2103024"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.12175","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.12175","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T10:03:53Z","timestamp":1696154633000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.12175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,20]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["10.1111\/ped.12175"],"URL":"https:\/\/doi.org\/10.1111\/ped.12175","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,20]]}}}