{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T14:00:20Z","timestamp":1792332020442,"version":"4.4.0"},"reference-count":10,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,12,11]],"date-time":"2013-12-11T00:00:00Z","timestamp":1386720000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We describe the case of a 3\u2010year\u2010old boy diagnosed with the fulminant form of acute disseminated encephalomyelitis (<jats:styled-content style=\"fixed-case\">ADEM<\/jats:styled-content>). He developed general fatigue, fever, drowsiness and difficulty in walking. He had extensive multiple high\u2010intensity lesions in the white matter of the cerebrum and cerebellum, which are typical findings of <jats:styled-content style=\"fixed-case\">ADEM<\/jats:styled-content>. He became comatose and developed decerebrate rigidity with severe brain edema despite high\u2010dose methylprednisolone therapy, and then was subjected to mild hypothermia therapy, and given i.v. immunoglobulin. The patient recovered remarkably with the sequela of only mild action tremor. The patient was considered to have acute hemorrhagic leukoencephalitis (<jats:styled-content style=\"fixed-case\">AHLE<\/jats:styled-content>), an extremely severe form of <jats:styled-content style=\"fixed-case\">ADEM<\/jats:styled-content>, in terms of the rapidly deteriorating clinical course and neuroimaging features. It was speculated that <jats:styled-content style=\"fixed-case\">AHLE<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ADEM<\/jats:styled-content> might be a continuous disease spectrum. It is considered that the severe brain edema associated with <jats:styled-content style=\"fixed-case\">ADEM<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">AHLE<\/jats:styled-content> is a suitable indication for mild hypothermia therapy.<\/jats:p>","DOI":"10.1111\/ped.12180","type":"journal-article","created":{"date-parts":[[2013,12,12]],"date-time":"2013-12-12T02:15:13Z","timestamp":1386814513000},"source":"Crossref","is-referenced-by-count":10,"title":["Fulminant form of acute disseminated encephalomyelitis in a child treated with mild hypothermia"],"prefix":"10.1111","volume":"55","author":[{"given":"Kazushi","family":"Ichikawa","sequence":"first","affiliation":[{"name":"Department of Pediatrics Yokohama City University Medical Center  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Motoi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Yokohama City University Medical Center  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Oyama","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Yokohama City University Medical Center  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Yokohama City University Medical Center  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saoko","family":"Takeshita","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Yokohama City University Medical Center  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,11]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2007.12.018"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-012-0170-0"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAF.0b013e3181c6be92"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/338718"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.rct.0000173843.82364.db"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000259422.44235.a8"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000048493.82053.4C"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(01)00256-X"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000156201.46473.A8"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(99)00089-1"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.12180","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.12180","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T10:04:24Z","timestamp":1696154664000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.12180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["10.1111\/ped.12180"],"URL":"https:\/\/doi.org\/10.1111\/ped.12180","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12]]}}}