{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T13:26:19Z","timestamp":1786973179206,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,9,18]],"date-time":"2013-09-18T00:00:00Z","timestamp":1379462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2013,12]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Children with acute liver failure (ALF<\/jats:styled-content>) caused by hemophagocytic lymphohistiocytosis (HLH<\/jats:styled-content>) may be at risk of undergoing unnecessary liver transplantation (LT<\/jats:styled-content>). The aim of this study was to compare the characteristics of ALF<\/jats:styled-content> caused by HLH<\/jats:styled-content> with those of ALF<\/jats:styled-content> of unknown etiology in children.<\/jats:p><\/jats:sec>Methods<\/jats:title>The clinical features and laboratory findings for eight children with ALF<\/jats:styled-content> caused by HLH<\/jats:styled-content> (ALF\u2010HLH<\/jats:styled-content> group) and 27 children with ALF<\/jats:styled-content> of unknown etiology (ALF\u2010UK<\/jats:styled-content> group) were retrospectively compared by reviewing medical records.<\/jats:p><\/jats:sec>Results<\/jats:title>The ALF\u2010HLH<\/jats:styled-content> group had a higher incidence of pleural effusion, C<\/jats:styled-content>\u2010reactive protein elevation (especially >5\u2009mg\/dL), thrombocytopenia, anemia, fever, splenomegaly, and hypoalbuminemia (<2.5\u2009mg\/dL), and a higher in\u2010hospital mortality rate. No significant differences were found in the white blood cell count, liver enzymes, coagulation profile, or incidence of hepatomegaly.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>LT<\/jats:styled-content> should be performed only after it is proven that ALF<\/jats:styled-content> is not caused by HLH<\/jats:styled-content>, if a child with ALF<\/jats:styled-content> shows the differential clinical features of ALF<\/jats:styled-content> caused by HLH<\/jats:styled-content>. Further research with larger sample sizes, however, is needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12181","type":"journal-article","created":{"date-parts":[[2013,7,12]],"date-time":"2013-07-12T10:20:03Z","timestamp":1373624403000},"page":"748-752","source":"Crossref","is-referenced-by-count":20,"title":["Differential clinical characteristics of acute liver failure caused by hemophagocytic lymphohistiocytosis in children"],"prefix":"10.1111","volume":"55","author":[{"given":"Jeong\u2010Min","family":"Ryu","sequence":"first","affiliation":[{"name":"Department of Pediatric Emergency Medicine Asan Medical Center Children's Hospital, University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Mo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Asan Medical Center Children's Hospital, University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seak Hee","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Asan Medical Center Children's Hospital, University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Nam","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Asan Medical Center Children's Hospital, University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho Joon","family":"Im","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Asan Medical Center Children's Hospital, University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan\u2010Jeoung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun\u2010Sook","family":"Chi","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Jin","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Asan Medical Center Children's Hospital, University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,9,18]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s100249900135"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e318198868b"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.12.051"},{"key":"e_1_2_5_5_1","first-page":"29","article-title":"Diagnostic guidelines for hemophagocytic lymphohistiocytosis. 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