{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T11:14:34Z","timestamp":1696245274832},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,12,11]],"date-time":"2013-12-11T00:00:00Z","timestamp":1386720000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2013,12]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Several drugs, when used chronically in very preterm infants, are considered to be associated with the development of late\u2010onset circulatory collapse (LCC<\/jats:styled-content>), which can lead to neurodevelopmental impairment. Despite its clinical importance, conclusive risk factors for LCC<\/jats:styled-content> have yet to be identified. The aim of the present study was to investigate the relationship between LCC<\/jats:styled-content> and diuretics, methylxanthines, levothyroxine, and sodium chloride.<\/jats:p><\/jats:sec>Methods<\/jats:title>Infants born at <28 weeks gestational age were enrolled and divided into two groups: the LCC<\/jats:styled-content> group and the non\u2010LCC<\/jats:styled-content> group. Use of diuretics, methylxanthines, or levothyroxine, and the sodium intake in each infant were recorded. We then determined if these represented primary risk factors associated with the development of LCC<\/jats:styled-content>, using multivariate analysis to exclude confounding factors.<\/jats:p><\/jats:sec>Results<\/jats:title>Thirty\u2010seven preterm infants were eligible for this study. LCC<\/jats:styled-content> developed in 10 infants; 27 infants did not develop the disease. Only methylxanthine was significantly associated with a decrease in the incidence of LCC<\/jats:styled-content> (odds ratio, 0.04; P<\/jats:styled-content><\/jats:italic> < 0.05). We also observed a significant positive correlation between sodium intake and the period from diuretic treatment to LCC<\/jats:styled-content> onset.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Methylxanthine use was significantly associated with LCC<\/jats:styled-content> onset. Diuretics may have the ability to provoke LCC<\/jats:styled-content> through sodium wasting, resulting in a negative balance of the electrolyte. The incidence of LCC<\/jats:styled-content> could be lowered by paying particular attention to infants' sodium balance, and by aggressive methylxanthine treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12184","type":"journal-article","created":{"date-parts":[[2013,8,12]],"date-time":"2013-08-12T13:21:02Z","timestamp":1376313662000},"page":"722-726","source":"Crossref","is-referenced-by-count":0,"title":["Methylxanthines inhibit late\u2010onset circulatory collapse in preterm infants"],"prefix":"10.1111","volume":"55","author":[{"given":"Kazuyuki","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Department of Pediatrics Ichinomiya Municipal Hospital Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunichi","family":"Terasawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ichinomiya Municipal Hospital Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Sahashi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ichinomiya Municipal Hospital Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoyuki","family":"Iwata","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ichinomiya Municipal Hospital Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshishige","family":"Miyake","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ichinomiya Municipal Hospital Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiko","family":"Hanji","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ichinomiya Municipal Hospital Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12,11]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2002.021972"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2008.02564.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2010.41"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2011.03518.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-994095"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2010.03072.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2010.23.1-2.153"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.110.137323"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6394(1997)5:1<21::AID-DA4>3.0.CO;2-8"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2008.06.003"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2011.11.001"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e31816c8fcc"},{"key":"e_1_2_5_14_1","first-page":"640","article-title":"Factors of late onset circulatory collapse in the early nutrient and electrolyte management of extremely premature infant (in Japanese)","volume":"42","author":"Oshiro M","year":"2006","journal-title":"J. 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