{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T11:34:41Z","timestamp":1774611281391,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,2,18]],"date-time":"2014-02-18T00:00:00Z","timestamp":1392681600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2014,2]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The relationship between hemoglobin and patent ductus arteriosus (PDA<\/jats:styled-content>) has not been discussed before. The aim of this study was to assess the influence of hemoglobin and perinatal factors on PDA<\/jats:styled-content> in very low\u2010birthweight (VLBW<\/jats:styled-content>) infants.<\/jats:p><\/jats:sec>Methods<\/jats:title>Using data from the P<\/jats:styled-content>remature B<\/jats:styled-content>aby F<\/jats:styled-content>oundation of T<\/jats:styled-content>aiwan (PBFA<\/jats:styled-content>), the characteristics, perinatal factors, and hemoglobin of VLBW<\/jats:styled-content> infants with and without PDA<\/jats:styled-content> and treatment were compared.<\/jats:p><\/jats:sec>Results<\/jats:title>Between J<\/jats:styled-content>anuary 2008 and D<\/jats:styled-content>ecember 2010, 89 VLBW<\/jats:styled-content> infants were admitted to hospital. The overall survival rate was 87.6%. Twelve infants were excluded. Compared to those without PDA<\/jats:styled-content>, the 34 infants with PDA<\/jats:styled-content> received oral indomethacin or surgery, had smaller mean gestational age (GA<\/jats:styled-content>; 27.93\u2009\u00b1\u20091.818\u2009weeks, P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.000003), lower mean birthweight (BW<\/jats:styled-content>; 1031\u2009\u00b1\u2009259\u2009g, P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.0001), significantly lower Apgar score at 5\u2009min, more severe respiratory distress syndrome (RDS<\/jats:styled-content>; grade 3 or 4), greater use of surfactants, and lower mean hemoglobin (P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.018) after birth than those without PDA<\/jats:styled-content>. Compared to those with indomethacin, the seven infants with surgery had lower mean GA<\/jats:styled-content> (26.43\u2009\u00b1\u20091.718\u2009weeks, P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.011), significantly lower A<\/jats:styled-content>pgar scores at 1\u2009min, but higher platelet count (P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.002) after birth, and more red blood cell transfusions (P<\/jats:italic>\u2009=\u20090.039).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Smaller GA<\/jats:styled-content>, lower BW<\/jats:styled-content>, lower Apgar score at 5\u2009min, more severe RDS<\/jats:styled-content>, greater use of surfactants, and lower hemoglobin after birth place VLBW<\/jats:styled-content> infants at greater risk of PDA<\/jats:styled-content>. Proper prenatal care, and prevention of premature labor and delivery may be the most important preventative factors. The appropriate hemoglobin level for PDA<\/jats:styled-content> closure requires further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12199","type":"journal-article","created":{"date-parts":[[2013,8,13]],"date-time":"2013-08-13T09:11:30Z","timestamp":1376385090000},"page":"72-76","source":"Crossref","is-referenced-by-count":22,"title":["Perinatal factors in patent ductus arteriosus in very low\u2010birthweight infants"],"prefix":"10.1111","volume":"56","author":[{"given":"Ying\u2010Yao","family":"Chen","sequence":"first","affiliation":[{"name":"Division of Neonatology Department of Pediatrics Kaohsiung Veterans General Hospital Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiao\u2010Ping","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Neonatology Department of Pediatrics Kaohsiung Veterans General Hospital Kaohsiung 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Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Taiwan Premature Infant Development Collaborative Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,18]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-072169347-7.50058-5"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-072169347-7.50032-9"},{"key":"e_1_2_5_4_1","first-page":"581","volume-title":"Nelson Textbook of Pediatrics","author":"Carlo WA","year":"2011"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2007.05.007"},{"key":"e_1_2_5_6_1","first-page":"388","article-title":"Risk factors for patent ductus arteriosus in neonates","volume":"13","author":"Qu XY","year":"2011","journal-title":"Zhongguo Dang Dai Er Ke Za 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