{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T11:14:37Z","timestamp":1696245277664},"reference-count":5,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,12,11]],"date-time":"2013-12-11T00:00:00Z","timestamp":1386720000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Reported herein is the first case of a remarkably delayed occurrence of normal surfactant composition in an extremely preterm infant who required a total of 15 doses of artificial pulmonary surfactant (<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>urfacten\u00ae). A male infant, born at 26 weeks gestation, developed respiratory distress at birth. Chest radiography was consistent with respiratory distress syndrome. The infant required repeated doses of surfactant, each resulting in transient periods of decreased ventilator requirement and improved blood gas values. Surfactant proteins (<jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>)\u2010<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> from tracheal aspirate samples were analyzed on the 13th day (deterioration period) and 36th day (recovery period) after birth. On the 13th day sufficient <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> but no <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> no <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> were detected on western blot analysis. <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> were eventually detected on the 36th day. This infant therefore required almost 3 months to achieve normal surfactant function.<\/jats:p>","DOI":"10.1111\/ped.12202","type":"journal-article","created":{"date-parts":[[2013,12,12]],"date-time":"2013-12-12T02:15:13Z","timestamp":1386814513000},"page":"790-792","source":"Crossref","is-referenced-by-count":1,"title":["Remarkably delayed occurrence of normal surfactant composition in an extremely preterm infant"],"prefix":"10.1111","volume":"55","author":[{"given":"Toshihiko","family":"Nakamura","sequence":"first","affiliation":[{"name":"Department of Pediatrics National Organization Hospital Nishi\u2010Saitama Chuo National Hospital  Tokorozawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Shimizu Children's Clinic  Konosu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiaki","family":"Nishitani","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiro","family":"Yoshioka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Organization Hospital Nishi\u2010Saitama Chuo National Hospital  Tokorozawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12,11]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(05)70111-1"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032178"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890701611094"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200304-479OC"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2003-0323OC"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.12202","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.12202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T10:04:35Z","timestamp":1696154675000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.12202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":5,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["10.1111\/ped.12202"],"URL":"https:\/\/doi.org\/10.1111\/ped.12202","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12]]}}}