{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T13:40:26Z","timestamp":1793886026240,"version":"4.8.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,2,18]],"date-time":"2014-02-18T00:00:00Z","timestamp":1392681600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To elucidate whether maternal vitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> supplementation during lactation improves infantile eczema and other subsequent allergic disorders, a randomized, double\u2010blind, placebo\u2010controlled trial was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Mothers (<jats:italic>n<\/jats:italic> = 164) of infants with facial eczema at 1 month check\u2010up were randomly assigned to receive vitamin <jats:styled-content style=\"fixed-case\">D3<\/jats:styled-content> supplements (<jats:italic>n<\/jats:italic> = 82; 800\u2009<jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\/day) or placebo (<jats:italic>n<\/jats:italic> = 82) for 6 weeks from <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ay 2009 to <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>anuary 2011. The primary outcome was infantile eczema quantified on Scoring Atopic Dermatitis (<jats:styled-content style=\"fixed-case\">SCORAD<\/jats:styled-content>) index at 3 month check\u2010up, and the secondary outcomes were atopic dermatitis, food allergy, and wheeze diagnosed by doctors up to 2 years of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no significant difference in <jats:styled-content style=\"fixed-case\">SCORAD<\/jats:styled-content> at 3 month check\u2010up between the two groups. Doctor\u2010diagnosed food allergy was significantly more common up to age 2 years in the vitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> group (10\/39, 25.7%) than in the placebo group (3\/40, 7.5%; risk ratio (RR), 3.42; 95% confidence interval [CI]: 1.02\u201311.77; <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic> = 0.030). Moreover, at least one secondary outcome was also significantly more common in the vitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> group (17\/39, 43.6%) than in the placebo group (7\/40, 17.5%; <jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>, 2.49; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.16\u20135.34; <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic> = 0.012).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Vitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> supplementation may not decrease the severity of infantile eczema at 3 months of age, but may rather increase the risk of later food allergy up to 2 years of age. Because a large number of subjects was lost to follow up, further study is needed to confirm the findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12207","type":"journal-article","created":{"date-parts":[[2013,9,4]],"date-time":"2013-09-04T13:55:02Z","timestamp":1378302902000},"page":"6-12","source":"Crossref","is-referenced-by-count":54,"title":["Increased food allergy and vitamin <scp>D<\/scp>: Randomized, double\u2010blind, placebo\u2010controlled trial"],"prefix":"10.1111","volume":"56","author":[{"given":"Chihiro","family":"Norizoe","sequence":"first","affiliation":[{"name":"Division of Molecular Epidemiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoe","family":"Akiyama","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Jikei University School of Medicine  Tokyo"},{"name":"Department of Pediatrics Fuji Chuo Hospital  Shizuoka 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