{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T21:45:25Z","timestamp":1781819125510,"version":"3.54.5"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,2,18]],"date-time":"2014-02-18T00:00:00Z","timestamp":1392681600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We describe a male neonate with classic maple syrup urine disease (<jats:styled-content style=\"fixed-case\">MSUD<\/jats:styled-content>) in metabolic crisis. On day 7 of life, he was referred to hospital because of coma and metabolic acidosis with maple syrup odor. On day 4 after admission, brain magnetic resonance imaging findings were consistent with encephalopathy due to<jats:styled-content style=\"fixed-case\">MSUD<\/jats:styled-content>. Proton magnetic resonance spectroscopy (<jats:styled-content style=\"fixed-case\"><jats:sup>1<\/jats:sup>H\u2010MRS<\/jats:styled-content>) showed a large methyl resonance peak at 0.9\u2009p.p.m. The diagnosis of<jats:styled-content style=\"fixed-case\">MSUD<\/jats:styled-content>was confirmed on low branched\u2010chain \u03b1\u2010keto acid dehydrogenase complex activity in lymphocyte.<jats:styled-content style=\"fixed-case\"><jats:sup>1<\/jats:sup>H\u2010MR<\/jats:styled-content>spectra were obtained in 10\u2009min, while it took at least several days to obtain the results of other diagnostic examinations. In convalescence, the peak at 0.9\u2009p.p.m. decreased. The large methyl resonance peak at 0.9\u2009p.p.m. in brain<jats:styled-content style=\"fixed-case\"><jats:sup>1<\/jats:sup>H\u2010MRS<\/jats:styled-content>would be one of the earliest clues to the diagnosis of classic<jats:styled-content style=\"fixed-case\">MSUD<\/jats:styled-content>in the neonatal period, especially in metabolic crisis.<\/jats:p>","DOI":"10.1111\/ped.12211","type":"journal-article","created":{"date-parts":[[2014,2,19]],"date-time":"2014-02-19T01:35:49Z","timestamp":1392773749000},"page":"112-115","source":"Crossref","is-referenced-by-count":18,"title":["Neonatal case of classic maple syrup urine disease: Usefulness of<scp><sup>1<\/sup>H\u2010MRS<\/scp>in early diagnosis"],"prefix":"10.1111","volume":"56","author":[{"given":"Takeshi","family":"Sato","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism Kanagawa Children's Medical Center Yokohama Japan"},{"name":"Department of Pediatrics Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Muroya","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Kanagawa Children's Medical Center Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junko","family":"Hanakawa","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Kanagawa Children's Medical Center Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumi","family":"Asakura","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Kanagawa Children's Medical Center Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Aida","sequence":"additional","affiliation":[{"name":"Department of Radiology Kanagawa Children's Medical Center Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moyoko","family":"Tomiyasu","sequence":"additional","affiliation":[{"name":"Research Center for Charged Particle Therapy National Institute of Radiological Sciences Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Go","family":"Tajima","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hiroshima University Graduate School of Biomedical and Health Sciences Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomonobu","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Adachi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Kanagawa Children's Medical Center Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,18]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.109.6.999"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.57.12.918"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.167.1.8659371"},{"key":"e_1_2_5_5_1","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S1052-5149(25)00540-4","article-title":"Proton MR spectroscopy of pediatric brain metabolic disorders","volume":"8","author":"Wang ZJ","year":"1998","journal-title":"Neuroimaging Clin. 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