{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T10:21:30Z","timestamp":1778494890673,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,2,18]],"date-time":"2014-02-18T00:00:00Z","timestamp":1392681600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Optimal nutritional status (NS) in cystic fibrosis (<jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content>) is associated with better lung function and increased overall survival. This study estimated the prevalence of malnutrition and obesity among <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content> patients in a tertiary center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a cross\u2010sectional study of 68 <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content> patients (33 female; 37 children\/adolescents) weight, height, body composition, respiratory function (% of the predicted forced expiratory volume in 1\u2009s; <jats:styled-content style=\"fixed-case\">FEV<\/jats:styled-content>1%<jats:sub>pred<\/jats:sub>) and serum lipids were measured; body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> standard deviation score (<jats:styled-content style=\"fixed-case\">BMI\u2010SDS<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> percentiles were calculated; <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>seudomonas<\/jats:italic> colonization, pancreatic insufficiency, diabetes mellitus (<jats:styled-content style=\"fixed-case\">CFDM<\/jats:styled-content>), liver disease (<jats:styled-content style=\"fixed-case\">CFLD<\/jats:styled-content>) and genotype were recorded; <jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content> was classified according to the 2005 Cystic Fibrosis Foundation (<jats:styled-content style=\"fixed-case\">CFF<\/jats:styled-content>) criteria. Frequency distributions and associations between anthropometric and clinical parameters (univariate\/multivariate) were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean age (\u00b1<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) was 19.81 \u00b1 8.98 years. Regarding <jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>: 22.1% were malnourished, 13.2% overweight\/obese and 29.4% had optimal <jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>. Pancreatic function (<jats:styled-content style=\"fixed-case\">PF<\/jats:styled-content>), <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>seudomonas<\/jats:italic> colonization, <jats:styled-content style=\"fixed-case\">CFDM<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">CFLD<\/jats:styled-content> and genotype differed significantly among the three groups. <jats:styled-content style=\"fixed-case\">FEV<\/jats:styled-content>1%<jats:sub>pred<\/jats:sub> was significantly higher among overweight\/obese patients and correlated positively with anthropometric characteristics as well as serum cholesterol and negatively with age. <jats:styled-content style=\"fixed-case\">BMI\u2010SDS<\/jats:styled-content> was associated with <jats:styled-content style=\"fixed-case\">PF<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">FEV1<\/jats:styled-content>%<jats:sub>pred<\/jats:sub> and <jats:styled-content style=\"fixed-case\">CFDM<\/jats:styled-content>. Among overweight\/obese patients 89.9% had adequate PF and 66.7% carried mutations other than F508del. No patient had any traits of metabolic syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite appropriate management only one\u2010third of the present patients had optimal <jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>. One\u2010fourth were malnourished and a significant percentage were overweight\/obese. The latter were mostly carriers of mutations other than F508del and had better pulmonary function. <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content> patients require intensive monitoring for both malnutrition and overweight\/obesity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12214","type":"journal-article","created":{"date-parts":[[2013,9,4]],"date-time":"2013-09-04T14:01:51Z","timestamp":1378303311000},"page":"89-94","source":"Crossref","is-referenced-by-count":52,"title":["Prevalence of malnutrition and obesity among cystic fibrosis patients"],"prefix":"10.1111","volume":"56","author":[{"given":"Paraskevi","family":"Panagopoulou","sequence":"first","affiliation":[{"name":"Fourth Pediatric Department Aristotle University of Thessaloniki Papageorgiou General Hospital  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Fotoulaki","sequence":"additional","affiliation":[{"name":"Fourth Pediatric Department Aristotle University of Thessaloniki Papageorgiou General Hospital  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aristidis","family":"Nikolaou","sequence":"additional","affiliation":[{"name":"Fourth Pediatric Department Aristotle University of Thessaloniki Papageorgiou General Hospital  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanda","family":"Nousia\u2010Arvanitakis","sequence":"additional","affiliation":[{"name":"Fourth Pediatric Department Aristotle University of Thessaloniki Papageorgiou General Hospital  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)83478-X"},{"key":"e_1_2_6_3_1","unstructured":"CFMDB Statistics. 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