{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:17:08Z","timestamp":1761743828907},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,28]],"date-time":"2014-01-28T00:00:00Z","timestamp":1390867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In premature infants, many factors influence the function of renal tubules, such as asphyxia, respiratory disorders, use of high\u2010concentration oxygen, hypotension, and drug treatment. When tubular ischemia and oxidative stress develop due to renal microcirculatory pathology, urinary <jats:bold><jats:sc>l<\/jats:sc><\/jats:bold>\u2010type fatty acid\u2010binding protein (<jats:sc>l<\/jats:sc>\u2010<jats:styled-content style=\"fixed-case\">FABP<\/jats:styled-content>) level increases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Urinary <jats:bold><jats:sc>l<\/jats:sc><\/jats:bold>\u2010<jats:styled-content style=\"fixed-case\">FABP<\/jats:styled-content> level was measured over time in very low\u2010birthweight infants (<jats:styled-content style=\"fixed-case\">VLBWI<\/jats:styled-content>), and the effect of fat emulsion on <jats:bold><jats:sc>l<\/jats:sc><\/jats:bold>\u2010<jats:styled-content style=\"fixed-case\">FABP<\/jats:styled-content> level was investigated. Thirty\u2010one <jats:styled-content style=\"fixed-case\">VLBWI<\/jats:styled-content> were divided into two groups with regard to treatment with fat emulsion: the lipid group (<jats:italic>n<\/jats:italic>\u2009=\u200920) and the control group (<jats:italic>n<\/jats:italic>\u2009=\u200911). Urinary <jats:bold><jats:sc>l<\/jats:sc><\/jats:bold>\u2010<jats:styled-content style=\"fixed-case\">FABP<\/jats:styled-content> was measured before (0\u20133 days of age), during (7\u201314 days of age), and after fat emulsion treatment (21\u201328 days of age) in the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median urinary <jats:bold><jats:sc>l<\/jats:sc><\/jats:bold>\u2010<jats:styled-content style=\"fixed-case\">FABP<\/jats:styled-content> level before treatment was 459\u2009ng\/mgCr (range, 22.7\u20135100\u2009ng\/mgCr; mean, 1067\u2009\u00b1\u20091570\u2009ng\/mgCr) and 797\u2009ng\/mgCr (range, 69\u20133900\u2009ng\/mgCr; mean, 1066\u2009\u00b1\u20091188\u2009ng\/mgCr) in the lipid and control groups, respectively, showing no significant difference. Median urinary <jats:bold><jats:sc>l<\/jats:sc><\/jats:bold>\u2010<jats:styled-content style=\"fixed-case\">FABP<\/jats:styled-content> level was 624\u2009ng\/mgCr (range, 50\u20132050\u2009ng\/mgCr; mean\u2009\u00b1\u2009SD, 799\u2009\u00b1\u2009655\u2009ng\/mgCr) and 273\u2009ng\/mgCr (range, 31\u2013987\u2009ng\/mgCr; mean\u2009\u00b1\u2009SD, 359\u2009\u00b1\u2009323\u2009ng\/mgCr) at 7\u201314 days of age, respectively, showing that the level was significantly higher in the lipid group. At 21\u201328 days of age, the median level was 462\u2009ng\/mgCr (range, 49\u20131867\u2009ng\/mgCr; mean\u2009\u00b1\u2009SD, 557\u2009\u00b1\u2009534\u2009ng\/mgCr) and 130\u2009ng\/mgCr (range, 20\u2013993\u2009ng\/mgCr; mean\u2009\u00b1\u2009SD, 290\u2009\u00b1\u2009329\u2009ng\/mgCr), respectively, showing that <jats:bold><jats:sc>l<\/jats:sc><\/jats:bold>\u2010<jats:styled-content style=\"fixed-case\">FABP<\/jats:styled-content> level tended to be higher in the lipid group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Fat emulsion treatment induced a significant increase in urinary <jats:bold><jats:sc>l<\/jats:sc><\/jats:bold>\u2010<jats:styled-content style=\"fixed-case\">FABP<\/jats:styled-content> level, suggesting that fat emulsion affected the proximal tubule in <jats:styled-content style=\"fixed-case\">VLBWI<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12223","type":"journal-article","created":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T21:59:30Z","timestamp":1381528770000},"page":"207-210","source":"Crossref","is-referenced-by-count":1,"title":["Fat emulsion given to very low\u2010birthweight infants increases urinary <scp>l<\/scp>\u2010<scp>FABP<\/scp>"],"prefix":"10.1111","volume":"56","author":[{"given":"Hiroki","family":"Suganuma","sequence":"first","affiliation":[{"name":"Neonatal Intensive Care Unit Shizuoka Hospital Juntendo University  Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naho","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit Shizuoka Hospital Juntendo University  Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natuki","family":"Ohkawa","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit Shizuoka Hospital Juntendo University  Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Nagata","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit Shizuoka Hospital Juntendo University  Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromichi","family":"Shoji","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Juntendo University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiaki","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Juntendo University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.5"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001703-200104000-00009"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-9422"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200207000-00010"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1542\/peds.91.1.83","article-title":"Toxic hydroperoxides in intravenous lipid emulsions used in preterm infants","volume":"91","author":"Helbock HJ","year":"1993","journal-title":"Pediatrics"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200308000-00015"},{"key":"e_1_2_6_8_1","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1093\/ajcn\/48.6.1394","article-title":"Increased lipid peroxidation after lipid infusion as measured by breath pentane output","volume":"48","author":"Van Gossum A","year":"1988","journal-title":"Am. 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