{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T22:57:16Z","timestamp":1759964236796},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,29]],"date-time":"2014-01-29T00:00:00Z","timestamp":1390953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acute pancreatitis in patients with severe motor and intellectual disability (<jats:styled-content style=\"fixed-case\">SMID<\/jats:styled-content>) is a rare but life\u2010threatening condition. Possible causes of acute pancreatitis in these patients including valproic acid therapy, hypothermia and nasoduodenal tube feeding, have not yet been investigated in detail. The aim of this study was therefore to investigate the risk factors for acute pancreatitis in patients with <jats:styled-content style=\"fixed-case\">SMID<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Five <jats:styled-content style=\"fixed-case\">SMID<\/jats:styled-content> patients with acute pancreatitis and 15 <jats:styled-content style=\"fixed-case\">SMID<\/jats:styled-content> patients without acute pancreatitis were reviewed. Age; serum total cholesterol, triglyceride, total protein, and albumin; height; bodyweight; body surface area; body mass index; daily calorie intake; daily calorie intake per unit of body mass surface area; daily calorie intake per kilogram bodyweight; and valproic acid usage were examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A statistically significant difference was observed in serum albumin level between the two groups (<jats:italic>P<\/jats:italic> = 0.026).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The mechanism of acute pancreatitis in these patients was considered as pancreatic morphological change, acinar damage, and elevated serum trypsinogen level caused by malnutrition. It is likely that acute pancreatitis in patients with <jats:styled-content style=\"fixed-case\">SMID<\/jats:styled-content> occurs due to the same mechanism as in anorexia nervosa and malnourished patients. To prevent acute pancreatitis in these patients, it is important to maintain adequate nutritional status.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12231","type":"journal-article","created":{"date-parts":[[2013,10,15]],"date-time":"2013-10-15T16:06:25Z","timestamp":1381853185000},"page":"240-243","source":"Crossref","is-referenced-by-count":7,"title":["Risk factors for acute pancreatitis in patients with severe motor and intellectual disabilities"],"prefix":"10.1111","volume":"56","author":[{"given":"Akiko","family":"Tamasaki","sequence":"first","affiliation":[{"name":"Division of Child Neurology Institute of Neurological Science Faculty of Medicine Tottori University  Yonago Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Division of Child Neurology Institute of Neurological Science Faculty of Medicine Tottori University  Yonago Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Kondo","sequence":"additional","affiliation":[{"name":"Division of Child Neurology Institute of Neurological Science Faculty of Medicine Tottori University  Yonago Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Shirai","sequence":"additional","affiliation":[{"name":"Division of Child Neurology Institute of Neurological Science Faculty of Medicine Tottori University  Yonago Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Maegaki","sequence":"additional","affiliation":[{"name":"Division of Child Neurology Institute of Neurological Science Faculty of Medicine Tottori University  Yonago Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kousaku","family":"Ohno","sequence":"additional","affiliation":[{"name":"Division of Child Neurology Institute of Neurological Science Faculty of Medicine Tottori University  Yonago Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-8994(02)00517-9"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2007.02002.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2006.04246.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/08830738040190070401"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00045391-200603000-00005"},{"key":"e_1_2_6_7_1","first-page":"231","article-title":"Recurrent acute pancreatitis in anorexia and bulimia","volume":"5","author":"Morris LG","year":"2004","journal-title":"JOP"},{"key":"e_1_2_6_8_1","first-page":"327","article-title":"Chronic pancreatitis in a patient with malnutrition due to anorexia nervosa","volume":"9","author":"Wesson RN","year":"2008","journal-title":"JOP"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1991.tb112850.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-199901000-00011"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/26.3.374"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.04.058"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.12.2.313"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1179\/146532808X302107"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.12231","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.12231","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T08:34:21Z","timestamp":1696149261000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.12231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,29]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1111\/ped.12231"],"URL":"https:\/\/doi.org\/10.1111\/ped.12231","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,29]]}}}