{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T16:45:59Z","timestamp":1732034759458},"reference-count":9,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,3,6]],"date-time":"2014-03-06T00:00:00Z","timestamp":1394064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The breathing intolerance index (<jats:styled-content style=\"fixed-case\">BITI<\/jats:styled-content>) is used to justify ventilator use in adult patients with pulmonary or chest wall disease. <jats:styled-content style=\"fixed-case\">BITI<\/jats:styled-content> in ventilated patients is mostly \u22650.15. The mean <jats:styled-content style=\"fixed-case\">BITI<\/jats:styled-content> of healthy adults in the upright sitting position and the supine position is 0.050 \u00b1 0.009 and 0.057 \u00b1 0.016, respectively. The aim of this study was to establish a normal <jats:styled-content style=\"fixed-case\">BITI<\/jats:styled-content> in infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty healthy infants were examined in the supine position. <jats:styled-content style=\"fixed-case\">BITI<\/jats:styled-content> was defined as <jats:styled-content style=\"fixed-case\">BITI<\/jats:styled-content> = (<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>i\/<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>tot) \u00d7 (<jats:styled-content style=\"fixed-case\">TV<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">VC<\/jats:styled-content>), where <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>i is inspiratory time, Ttot is total breath cycle duration, <jats:styled-content style=\"fixed-case\">TV<\/jats:styled-content> is tidal volume, and <jats:styled-content style=\"fixed-case\">VC<\/jats:styled-content> is vital capacity. <jats:styled-content style=\"fixed-case\">TV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>i\/<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>tot were obtained from tidal breathing at rest and <jats:styled-content style=\"fixed-case\">VC<\/jats:styled-content> was obtained spirometrically. <jats:styled-content style=\"fixed-case\">BITI<\/jats:styled-content> was calculated using customized software.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean \u00b1 <jats:styled-content style=\"fixed-case\">SD BITI<\/jats:styled-content> of 30 healthy infants in the supine position was 0.120 \u00b1 0.013. The <jats:styled-content style=\"fixed-case\">BITI<\/jats:styled-content> of infants was significantly higher than that of adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">BITI<\/jats:styled-content> was measured in healthy infants. Further evaluation is needed to determine the significance and usefulness of <jats:styled-content style=\"fixed-case\">BITI<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12247","type":"journal-article","created":{"date-parts":[[2013,11,26]],"date-time":"2013-11-26T12:53:58Z","timestamp":1385470438000},"page":"227-229","source":"Crossref","is-referenced-by-count":2,"title":["Breathing intolerance index in healthy infants"],"prefix":"10.1111","volume":"56","author":[{"given":"Hisaya","family":"Hasegawa","sequence":"first","affiliation":[{"name":"Division of Neonatal Intensive Care Tokyo Women's Medical University Medical Center East  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhide","family":"Henmi","sequence":"additional","affiliation":[{"name":"Division of Neonatal Intensive Care Tokyo Women's Medical University Medical Center East  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shio","family":"Tsuruta","sequence":"additional","affiliation":[{"name":"Division of Neonatal Intensive Care Tokyo Women's Medical University Medical Center East  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitaka","family":"Miyoshi","sequence":"additional","affiliation":[{"name":"Division of Neonatal Intensive Care Tokyo Women's Medical University Medical Center East  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yousuke","family":"Yamada","sequence":"additional","affiliation":[{"name":"Division of Neonatal Intensive Care Tokyo Women's Medical University Medical Center East  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichi","family":"Muto","sequence":"additional","affiliation":[{"name":"Division of Neonatal Intensive Care Tokyo Women's Medical University Medical Center East  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Wasa","sequence":"additional","affiliation":[{"name":"Division of Neonatal Intensive Care Tokyo Women's Medical University Medical Center East  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,6]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1982.53.5.1190"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.phm.0000184237.62628.e1"},{"key":"e_1_2_5_4_1","first-page":"249","article-title":"Indication for mechanical ventilation in adults with acute respiratory failure","volume":"47","author":"Pierson DJ","year":"2002","journal-title":"Respir. 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