{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T16:45:31Z","timestamp":1783615531813,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,3,10]],"date-time":"2014-03-10T00:00:00Z","timestamp":1394409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2014,6]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Perinatal hypoxic\u2013ischemic encephalopathy (HIE<\/jats:styled-content>) has been linked to the development of late\u2010onset seizures. The aim of the present study was to determine the incidence of epilepsy and W<\/jats:styled-content>est syndrome in children with perinatal HIE<\/jats:styled-content> and identify factors associated with the development of postnatal seizure disorders.<\/jats:p><\/jats:sec>Methods<\/jats:title>We retrospectively enrolled 208 term and late\u2010preterm infants diagnosed with perinatal HIE<\/jats:styled-content> from A<\/jats:styled-content>pril 2000 to M<\/jats:styled-content>arch 2009 at Saitama Children's Medical Center. Children with obvious multiple anomalies and known chromosomal abnormalities were excluded. A questionnaire was distributed to parents to determine seizure\u2010related outcomes. Medical records were retrospectively reviewed and relevant clinical parameters were analyzed.<\/jats:p><\/jats:sec>Results<\/jats:title>In total, 162 questionnaires were answered (77.9%). Of the 162 subjects, 26 (16.0%) developed epilepsy, and eight subjects (4.9%) were diagnosed with West syndrome. Neonatal seizures occurred in 72 subjects (44.4%). The incidence of epilepsy and West syndrome was significantly higher in infants who experienced neonatal seizures than in those without seizure history. A total of 82 subjects were diagnosed with moderate (n<\/jats:italic> = 52) or severe HIE<\/jats:styled-content> (n<\/jats:italic> = 30), of whom 57 subjects (69.5%) received therapeutic hypothermia. The incidence of epilepsy was significantly lower in these treated subjects. In addition, subjects with moderate or severe HIE<\/jats:styled-content> were significantly more likely to develop late\u2010onset epilepsy and West syndrome than those with mild HIE<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The severity of perinatal HIE<\/jats:styled-content> and neonatal seizures is a potential risk factor for the development of late\u2010onset seizures. Therapeutic hypothermia may reduce the risk of the development of epilepsy in such cases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12257","type":"journal-article","created":{"date-parts":[[2013,11,26]],"date-time":"2013-11-26T12:28:44Z","timestamp":1385468924000},"page":"369-372","source":"Crossref","is-referenced-by-count":25,"title":["Epilepsy and W<\/scp>est syndrome in neonates with hypoxic\u2013ischemic encephalopathy"],"prefix":"10.1111","volume":"56","author":[{"given":"Takeshi","family":"Inoue","sequence":"first","affiliation":[{"name":"Department of Pediatrics Dokkyo Medical University Koshigaya Hospital Koshigaya Japan"},{"name":"Division of Neonatology Saitama Children's Medical Center Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Division of Neonatology Saitama Children's Medical Center Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin\u2010ichiro","family":"Hamano","sequence":"additional","affiliation":[{"name":"Division of Neurology Saitama Children's Medical Center Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Dokkyo Medical University Koshigaya Hospital Koshigaya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiro","family":"Nagai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Dokkyo Medical University Koshigaya Hospital Koshigaya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoichi","family":"Sakuta","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Dokkyo Medical University Koshigaya Hospital Koshigaya 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