{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T22:53:44Z","timestamp":1768258424042,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2014,6]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Previous studies suggested that leukotrienes (LT<\/jats:styled-content>) were involved in the pathogenesis of H<\/jats:styled-content>enoch\u2013S<\/jats:styled-content>ch\u00f6nlein purpura (HSP<\/jats:styled-content>). This study investigated the efficacy of an add\u2010on therapy with montelukast in the treatment of HSP<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>In this four\u2010center, double\u2010blind, placebo\u2010controlled, parallel paired comparative study, 130 children with HSP<\/jats:styled-content> were divided into two large groups: 84 patients without nephritis and 46 patients with nephritis. For each pair of patients with the same severity of disease, one subject was randomly allocated to one subgroup and the other allocated to the other subbroup; one subgroup received routine treatment plus placebo treatment, while the other subgroup received routine treatment plus montelukast treatment for 3 months. The efficacy was determined using Severity Scale Score (SSS<\/jats:styled-content>). Blood eosinophil count, eosinophil cationic protein (ECP<\/jats:styled-content>), IgE<\/jats:styled-content>, interleukin (IL<\/jats:styled-content>)\u20104, IL<\/jats:styled-content>\u20105, IL<\/jats:styled-content>\u20106, IL<\/jats:styled-content>\u20108, IL<\/jats:styled-content>\u201017, LTB<\/jats:styled-content>4<\/jats:sub>, and urinary LTE<\/jats:styled-content>4<\/jats:sub> were measured.<\/jats:p><\/jats:sec>Results<\/jats:title>Add\u2010on therapy with montelukast alleviated the symptoms of HSP<\/jats:styled-content> including purpura, abdominal pain, stool occult blood, arthritis, proteinuria and hematuria, and, accordingly, shortened the length of hospital stay, and lowered blood eosinophil count, ECP<\/jats:styled-content>, IgE<\/jats:styled-content>, IL<\/jats:styled-content>\u20104, IL<\/jats:styled-content>\u20105, IL<\/jats:styled-content>\u20106, IL<\/jats:styled-content>\u20108, IL<\/jats:styled-content>\u201017, LTB<\/jats:styled-content>4<\/jats:sub>, and urinary LTE<\/jats:styled-content>4<\/jats:sub> production, and also lowered the HSP<\/jats:styled-content> relapse rate during the 3 months of treatment, but did not alter the outcome of nephritis at the end of follow up.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Add\u2010on therapy with montelukast alleviated the symptoms of HSP<\/jats:styled-content>. HSP<\/jats:styled-content> may be improved by add\u2010on therapy with a leukotriene receptor antagonist.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12271","type":"journal-article","created":{"date-parts":[[2013,12,2]],"date-time":"2013-12-02T12:35:03Z","timestamp":1385987703000},"page":"315-322","source":"Crossref","is-referenced-by-count":19,"title":["Add\u2010on therapy with montelukast in the treatment of H<\/scp>enoch\u2013S<\/scp>ch\u00f6nlein purpura"],"prefix":"10.1111","volume":"56","author":[{"given":"Sheng\u2010Hua","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Pediatrics First Affiliated Hospital with Nanjing Medical University Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei\u2010Yuan","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Central Hospital of Tengzhou Tengzhou Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Qing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Jiangsu Maternity and Children Healthcare Hospital Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei\u2010Ling","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Nanjing First Hospital Affiliated to Nanjing Medical University Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Pediatrics First Affiliated Hospital with Nanjing Medical University Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,4]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"804","volume-title":"Textbook of Nephrology","author":"Haycock GB","year":"2001"},{"key":"e_1_2_6_3_1","first-page":"1675","volume-title":"Rheumatology","author":"Szer IS","year":"2003"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00865470"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-009-1230-x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200x.2005.02115.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2011.01198.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-011-2266-3"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2004.03.029"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2004.02029.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0952-3278(94)90246-1"},{"key":"e_1_2_6_12_1","first-page":"272","article-title":"Relationship between leukotrienes and clinical, pathological features of Henoch\u2010Sch\u00f6enlein purpura nephritis in children","volume":"46","author":"Chen XY","year":"2008","journal-title":"Chin. 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