{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T11:41:07Z","timestamp":1776771667195,"version":"3.51.2"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,2,18]],"date-time":"2014-02-18T00:00:00Z","timestamp":1392681600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Atypical hemolytic uremic syndrome (<jats:styled-content style=\"fixed-case\">aHUS<\/jats:styled-content>) is rare and comprises the triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury. Recently, abnormalities in the mechanisms underlying complement regulation have been focused upon as causes of <jats:styled-content style=\"fixed-case\">aHUS<\/jats:styled-content>. The prognosis for patients who present with <jats:styled-content style=\"fixed-case\">aHUS<\/jats:styled-content> is very poor, with the first <jats:styled-content style=\"fixed-case\">aHUS<\/jats:styled-content> attack being associated with a mortality rate of approximately 25%, and with approximately 50% of cases resulting in end\u2010stage renal disease requiring dialysis. If treatment is delayed, there is a high risk of this syndrome progressing to renal failure. Therefore, we have developed diagnostic criteria for <jats:styled-content style=\"fixed-case\">aHUS<\/jats:styled-content> to enable its early diagnosis and to facilitate the timely initiation of appropriate treatment. We hope these diagnostic criteria will be disseminated to as many clinicians as possible and that they will be used widely.<\/jats:p>","DOI":"10.1111\/ped.12274","type":"journal-article","created":{"date-parts":[[2014,2,19]],"date-time":"2014-02-19T01:35:49Z","timestamp":1392773749000},"page":"1-5","source":"Crossref","is-referenced-by-count":26,"title":["Diagnostic criteria for atypical hemolytic uremic syndrome proposed by the <scp>J<\/scp>oint <scp>C<\/scp>ommittee of the <scp>J<\/scp>apanese <scp>S<\/scp>ociety of <scp>N<\/scp>ephrology and the <scp>J<\/scp>apan <scp>P<\/scp>ediatric <scp>S<\/scp>ociety"],"prefix":"10.1111","volume":"56","author":[{"given":"Toshihiro","family":"Sawai","sequence":"first","affiliation":[{"name":"Department of Pediatrics Shiga University of Medical Science  Otsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaomi","family":"Nangaku","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Endocrinology University of Tokyo School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Ashida","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Osaka Medical College  Takatsuki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rika","family":"Fujimaru","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Osaka City General Hospital  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Hataya","sequence":"additional","affiliation":[{"name":"Department of Nephrology Tokyo Metropolitan Children's Medical Center  Fuchu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiko","family":"Hidaka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Kaname","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine Kyorin University School of Medicine  Mitaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirokazu","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Nephrology Faculty of Medicine Saitama Medical University  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waichi","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Nephrology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension Department of Medicine St Marianna University School of Medicine  Kawasaki 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