{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T19:01:53Z","timestamp":1702580513992},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,6,3]],"date-time":"2014-06-03T00:00:00Z","timestamp":1401753600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2014,6]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Central venous catheterization is recognized as a lifeline that is important for chemotherapy or nutritional support in pediatric patients with malignant disease and intestinal failure. This study analyzed the risk of infection with B<\/jats:styled-content>roviac line use among these patients at a single J<\/jats:styled-content>apanese center.<\/jats:p><\/jats:sec>Methods<\/jats:title>Two hundred and four B<\/jats:styled-content>roviac lines were inserted in patients in the pediatric ward from J<\/jats:styled-content>anuary 2003 to O<\/jats:styled-content>ctober 2011. We analyzed the risk of catheter\u2010related bloodstream infection (CR\u2010BSI<\/jats:styled-content>) using clinical characteristics including underlying disease, sepsis history, inserted situation, drug use, and laboratory data at the time of B<\/jats:styled-content>roviac insertion or before CR\u2010BSI<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>During the study period, data from a total of 15 lines were excluded because of missing blood culture data. In the remaining 189 B<\/jats:styled-content>roviac lines, 52 lines developed CR\u2010BSI<\/jats:styled-content>. On univariate analysis, leukemia, infantile C<\/jats:styled-content>rohn's disease, sepsis history before B<\/jats:styled-content>roviac insertion, existence of a stoma opening, and immunosuppressant use before CR\u2010BSI<\/jats:styled-content> were risk factors for CR\u2010BSI<\/jats:styled-content>. On multivariate logistic regression analysis infantile C<\/jats:styled-content>rohn's disease, sepsis history before B<\/jats:styled-content>roviac insertion, and immunosuppressant use before CR\u2010BSI<\/jats:styled-content> were independently associated with CR\u2010BSI<\/jats:styled-content> (P<\/jats:italic> = 0.015, P<\/jats:italic> = 0.045, and P<\/jats:italic> = 0.043, respectively).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Infantile C<\/jats:styled-content>rohn's disease carries a high risk for CR\u2010BSI<\/jats:styled-content> because of its pathological condition, the therapeutic drugs required, and surgical intervention.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12304","type":"journal-article","created":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T12:28:14Z","timestamp":1392208094000},"page":"364-368","source":"Crossref","is-referenced-by-count":3,"title":["Infantile C<\/scp>rohn's disease is one of the risk factors for catheter\u2010related bloodstream infection"],"prefix":"10.1111","volume":"56","author":[{"given":"Yuhki","family":"Koike","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal and Pediatric Surgery Mie University Graduate School of Medicine Tsu Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Pediatric Surgery Mie University Graduate School of Medicine Tsu Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikihiro","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Pediatric Surgery Mie University Graduate School of Medicine Tsu Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shozo","family":"Ide","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Pediatric Surgery Mie University Graduate School of Medicine Tsu Mie 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Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshimitsu","family":"Araki","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Pediatric Surgery Mie University Graduate School of Medicine Tsu Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minako","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Pediatric Surgery Mie University Graduate School of Medicine Tsu Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiko","family":"Mohri","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Pediatric Surgery Mie University Graduate School of Medicine Tsu Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Kusunoki","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Pediatric Surgery Mie University Graduate School of Medicine 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