{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:35:19Z","timestamp":1790231719464,"version":"4.1.0"},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T00:00:00Z","timestamp":1413936000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this report we describe the upper gastrointestinal tractus involvement in a rare genetic disease of lipid metabolism. A 12\u2010year\u2010old boy presented with sore throat and fever. On physical examination, orange\u2013yellow tonsils and adenoid tissue were noted. Mild hepatosplenomegaly was present. Lipid profile was compatible with <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>angier disease (<jats:styled-content style=\"fixed-case\">TD<\/jats:styled-content>). Endoscopy of the upper gastrointestinal tract showed white\u2010yellowish fatty deposits on the gastric mucosa. Microscopically, biopsy specimens contained numerous histiocytes with a foamy cytoplasm packed in the lamina propria of the gastric mucosa and at the crypt basement of the duodenum. His sister, 8 years old, was also diagnosed with <jats:styled-content style=\"fixed-case\">TD<\/jats:styled-content> based on abnormal lipid profile and orange\u2013yellow tonsils. <jats:styled-content style=\"fixed-case\">TD<\/jats:styled-content> is a rare familial disorder of lipid metabolism, characterized by deposition of cholesteryl esters, probably involving the entirety of the gastrointestinal tract from the mouth to the anus.<\/jats:p>","DOI":"10.1111\/ped.12306","type":"journal-article","created":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T06:49:30Z","timestamp":1413960570000},"page":"777-779","source":"Crossref","is-referenced-by-count":7,"title":["Tangier disease in a <scp>T<\/scp>urkish family"],"prefix":"10.1111","volume":"56","author":[{"given":"Neriman","family":"Sahiner","sequence":"first","affiliation":[{"name":"Department of Dermatology K\u0131r\u0131kkale University Faculty of Medicine  Kirikkale Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukadder","family":"Kocak","sequence":"additional","affiliation":[{"name":"Department of Dermatology K\u0131r\u0131kkale University Faculty of Medicine  Kirikkale Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulya","family":"Demirceken","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology K\u0131r\u0131kkale University Faculty of Medicine  Kirikkale Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ucler","family":"Kisa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry K\u0131r\u0131kkale University Faculty of Medicine  Kirikkale Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebnem","family":"Ayva","sequence":"additional","affiliation":[{"name":"Department of Pathology K\u0131r\u0131kkale University Faculty of Medicine  Kirikkale Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Kazkayasi","sequence":"additional","affiliation":[{"name":"Ear Nose and Throat K\u0131r\u0131kkale University Faculty of Medicine  Kirikkale Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,22]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-55-6-1016"},{"key":"e_1_2_5_3_1","first-page":"2937","volume-title":"The Metabolic and Molecular Basis of Inherited Diseases","author":"Assman G","year":"2001"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/11921"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199605233342108"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199808000-00022"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.0406"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/98.2.191"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0954-6820.2003.01256.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.24.7.609"},{"key":"e_1_2_5_11_1","first-page":"101","article-title":"The pathology of Tangier disease: A light and electron microscopic study","volume":"78","author":"Ferrans VJ","year":"1975","journal-title":"Am. 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Pathol."}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.12306","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.12306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T12:25:54Z","timestamp":1696163154000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.12306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1111\/ped.12306"],"URL":"https:\/\/doi.org\/10.1111\/ped.12306","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10]]}}}