{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:48:12Z","timestamp":1783471692134,"version":"3.55.0"},"reference-count":8,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,9,24]],"date-time":"2014-09-24T00:00:00Z","timestamp":1411516800000},"content-version":"vor","delay-in-days":54,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>ilson's disease (<jats:styled-content style=\"fixed-case\">WD<\/jats:styled-content>) is an autosomal recessive defect in cellular copper transportation. Although acute lymphoblastic leukemia (<jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>) is the most common form of childhood malignancy, only two cases of <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> associated with <jats:styled-content style=\"fixed-case\">WD<\/jats:styled-content> have been reported to date. One patient died of relapse and infection, and the other died of neutropenic sepsis during the treatment. We here describe the case of a 10\u2010year\u2010old girl with <jats:styled-content style=\"fixed-case\">WD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>. Adverse events of chemotherapy, including liver toxicity and severe myelosuppression, necessitated adjustments in the chemotherapy doses. After completion of the treatment, the patient has remained in remission from <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> without progression of liver damage for 2 years. Severe treatment\u2010related toxicity should be considered in chemotherapy for patients with <jats:styled-content style=\"fixed-case\">WD<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/ped.12313","type":"journal-article","created":{"date-parts":[[2014,9,24]],"date-time":"2014-09-24T06:25:25Z","timestamp":1411539925000},"page":"626-629","source":"Crossref","is-referenced-by-count":6,"title":["Acute lymphoblastic leukemia in a girl with <scp>W<\/scp>ilson's disease"],"prefix":"10.1111","volume":"56","author":[{"given":"Sayaka","family":"Maeda","sequence":"first","affiliation":[{"name":"Department of Pediatrics Kyoto University Hospital  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Matsubara","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kyoto University Hospital  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eitaro","family":"Hiejima","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kyoto University Hospital  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kyoto University Hospital  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Tenri Hospital  Tenri Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itaru","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kyoto University Hospital  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsutsugu","family":"Umeda","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kyoto University Hospital  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidefumi","family":"Hiramatsu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kyoto University Hospital  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken\u2010ichiro","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kyoto University Hospital  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Heike","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kyoto University Hospital  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souichi","family":"Adachi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine School of Human Health Sciences Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,24]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1982.03330040055032"},{"key":"e_1_2_4_3_1","first-page":"256","article-title":"Acute lymphoblastic leukemia in a child with Wilson disease","volume":"42","author":"Y\u00fcce A","year":"2000","journal-title":"Turk. 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