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Although\n                    <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\n                    \u2010infected\n                    <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\n                    cells have the potential for unlimited proliferation, they are effectively removed by the virus\u2010specific cytotoxic\n                    <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\n                    cells, and\n                    <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\n                    \u2010associated lymphoproliferative disease develops only in immunocompromised hosts. Rarely, however, individuals without apparent immunodeficiency develop chronic\n                    <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\n                    infection with persistent infectious mononucleosis\u2010like symptoms. These patients have high\n                    <jats:styled-content style=\"fixed-case\">EBV\u2010DNA<\/jats:styled-content>\n                    load in the peripheral blood and systemic clonal expansion of\n                    <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\n                    \u2010infected\n                    <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\n                    cells or natural killer (\n                    <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content>\n                    ) cells. Their prognosis is poor with life\u2010threatening complications including hemophagocytic lymphohistiocytosis, organ failure, and malignant lymphomas. The term \u201cchronic active\n                    <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\n                    infection\u201d (\n                    <jats:styled-content style=\"fixed-case\">CAEBV<\/jats:styled-content>\n                    ) is now generally used for this disease. The geographical distribution of\n                    <jats:styled-content style=\"fixed-case\">CAEBV<\/jats:styled-content>\n                    is markedly uneven and most cases have been reported from\n                    <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>\n                    apan and other\n                    <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>\n                    ast\n                    <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\n                    sian countries. Here we summarize the current understanding of\n                    <jats:styled-content style=\"fixed-case\">CAEBV<\/jats:styled-content>\n                    and describe the recent progress of\n                    <jats:styled-content style=\"fixed-case\">CAEBV<\/jats:styled-content>\n                    research in\n                    <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>\n                    apan.\n                  <\/jats:p>","DOI":"10.1111\/ped.12314","type":"journal-article","created":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T06:42:57Z","timestamp":1392619377000},"page":"159-166","source":"Crossref","is-referenced-by-count":77,"title":["Current research on chronic active\n                    <scp>E<\/scp>\n                    pstein\u2013\n                    <scp>B<\/scp>\n                    arr virus infection in\n                    <scp>J<\/scp>\n                    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