{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T22:10:59Z","timestamp":1773267059253,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,5,30]],"date-time":"2014-05-30T00:00:00Z","timestamp":1401408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to clarify the outcome of patients with cardiovascular malformation (<jats:styled-content style=\"fixed-case\">CVM<\/jats:styled-content>) among those with congenital diaphragmatic hernia (<jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content>) who are indicated for the <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ontan procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The subjects included 76 <jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content> patients with <jats:styled-content style=\"fixed-case\">CVM<\/jats:styled-content> recruited from a national survey of 614 <jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content> patients. The outcomes were evaluated between two groups divided according to indication for the <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ontan procedure. Patients with functional univentricular disease were considered to be candidates for the Fontan procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixteen (21.1%) of the 76 patients were candidates for the Fontan procedure, accounting for 2.6% of all 614 patients with <jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content>. None of these patients, however, underwent the <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ontan procedure. Among the 16 patients, the absence of obstruction of the left ventricular outflow tract (<jats:styled-content style=\"fixed-case\">LVOTO<\/jats:styled-content>) was significantly associated with better 90\u2009day survival (71.4%, 5\/7, for those without <jats:styled-content style=\"fixed-case\">LVOTO<\/jats:styled-content> vs 0.0%, 0\/9, for those with <jats:styled-content style=\"fixed-case\">LVOTO<\/jats:styled-content>, <jats:italic>P<\/jats:italic> = 0.0007). After excluding 22 patients with chromosomal and\/or genetic abnormalities or syndromes, the 90\u2009day survival rate was significantly better in neonates without than with indication for the Fontan procedure (62.5%, 25\/40 vs 28.6%, 4\/14, <jats:italic>P<\/jats:italic> = 0.0271).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with indications for the Fontan procedure are rare, and the outcome of patients with <jats:styled-content style=\"fixed-case\">LVOTO<\/jats:styled-content> among those with <jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content> is especially poor.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12322","type":"journal-article","created":{"date-parts":[[2014,3,10]],"date-time":"2014-03-10T12:56:46Z","timestamp":1394456206000},"page":"553-558","source":"Crossref","is-referenced-by-count":3,"title":["Outcome of congenital diaphragmatic hernia with indication for Fontan procedure"],"prefix":"10.1111","volume":"56","author":[{"given":"Nobuko","family":"Shiono","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiology Osaka Medical Center and Research Institute for Maternal and Child Health  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noboru","family":"Inamura","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Osaka Medical Center and Research Institute for Maternal and Child Health  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigehiro","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Division of Neonatology Department of Maternal and Perinatal Medicine National Center for Child Health and Development  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouji","family":"Nagata","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Reproductive and Developmental Medicine, Graduate School of Medical Sciences, Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Fujino","sequence":"additional","affiliation":[{"name":"Intensive Care Unit Osaka University Hospital  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Hayakawa","sequence":"additional","affiliation":[{"name":"Department of Maternal and Perinatal Care Center Nagoya University Hospital  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriaki","family":"Usui","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Osaka University, Graduate School of Medicine  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroomi","family":"Okuyama","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Hyogo College of Medicine University  Hyogo 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