{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:55:50Z","timestamp":1759938950983},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,6,17]],"date-time":"2014-06-17T00:00:00Z","timestamp":1402963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2014,10]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Despite the early use of phototherapy and exchange transfusion in premature infants based on total serum bilirubin (TSB<\/jats:styled-content>), the reemergence of kernicterus has been reported. The aim of this study was to assess the validity of using TSB<\/jats:styled-content> as the criterion for phototherapy in extremely low\u2010birthweight infants (ELBWI<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>We reviewed the medical charts of 43 ELBWI<\/jats:styled-content> admitted to hospital between J<\/jats:styled-content>anuary 2009 and D<\/jats:styled-content>ecember 2010, and analyzed the relationship between TSB<\/jats:styled-content> and unbound bilirubin (UB<\/jats:styled-content>).<\/jats:p><\/jats:sec>Results<\/jats:title>No infant underwent exchange transfusion or developed acute bilirubin encephalopathy. There was a significant correlation between TSB<\/jats:styled-content> and UB<\/jats:styled-content> measured immediately before phototherapy during the first 7 days of life (r<\/jats:italic> = 0.657, P<\/jats:italic> < 0.001), but none thereafter (r =<\/jats:italic> 0.120, P =<\/jats:italic> 0.213). Thirty\u2010seven percent of infants who underwent phototherapy during the first 7 days of life had suprathreshold USB<\/jats:styled-content> but subthreshold TSB<\/jats:styled-content>, whereas this rose to 97% thereafter.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>No correlation was observed between TSB<\/jats:styled-content> and UB<\/jats:styled-content> in ELBWI<\/jats:styled-content> after the first 7 days of life, and almost all phototherapy sessions were initiated based on the UB<\/jats:styled-content> criterion, even though TSB<\/jats:styled-content> was below the accepted threshold. UB<\/jats:styled-content> may be high if jaundice is evaluated solely on the basis of TSB<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12351","type":"journal-article","created":{"date-parts":[[2014,4,2]],"date-time":"2014-04-02T07:33:12Z","timestamp":1396423992000},"page":"731-734","source":"Crossref","is-referenced-by-count":7,"title":["Problems with using total serum bilirubin as a criterion for phototherapy in extremely low\u2010birthweight infants"],"prefix":"10.1111","volume":"56","author":[{"given":"Kenji","family":"Ichinomiya","sequence":"first","affiliation":[{"name":"Department of Neonatology Gunma Children's Medical Center Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumitaka","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Neonatology Gunma Children's Medical Center Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aya","family":"Koizumi","sequence":"additional","affiliation":[{"name":"Department of Neonatology Gunma Children's Medical Center Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Neonatology Gunma Children's Medical Center Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Fujiu","sequence":"additional","affiliation":[{"name":"Department of Neonatology Gunma Children's Medical Center Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Department of Neonatology Gunma Children's Medical Center Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,6,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.1992.tb01024.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2000.108566"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2000.tb00738.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-2468"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.6.1256"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.84.2.F136"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-8994(01)00306-X"},{"key":"e_1_2_6_9_1","first-page":"225","volume-title":"Management of Premature and Newborn Infants.]","author":"Nakamura H","year":"2000"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(77)90437-5"},{"key":"e_1_2_6_11_1","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1542\/peds.45.6.906","article-title":"Kernicterus: High incidence in premature infants with low serum bilirubin concentrations","volume":"45","author":"Gartner LM","year":"1970","journal-title":"Pediatrics"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.93.3.488"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-2791"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-3024"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2009.02878.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2012.71"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2011.04.004"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0803024"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2007.134056"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2006.09.006"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000314893"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-0395"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.12351","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.12351","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T12:25:17Z","timestamp":1696163117000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.12351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,17]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1111\/ped.12351"],"URL":"https:\/\/doi.org\/10.1111\/ped.12351","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,17]]}}}