{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:43:48Z","timestamp":1776732228034,"version":"3.51.2"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,9,26]],"date-time":"2014-09-26T00:00:00Z","timestamp":1411689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Health and Welfare of Japan"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to describe the prevalence of esophageal atresia\/stenosis and small intestinal atresia\/stenosis in <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>agano, <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apan, together with associated anomalies, prenatal diagnosis and survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A population\u2010based cohort study of the prevalence of esophageal atresia\/stenosis and small intestinal atresia\/stenosis was conducted in <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>agano in <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>anuary 1993\u2013<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ecember 2011. The <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ann\u2013<jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>hitney test, \u03c7<jats:sup>2<\/jats:sup> test and <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>ruskal\u2013<jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>allis test were used to compare variables. <jats:italic>P<\/jats:italic> &lt; 0.05 was considered statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 74 cases of esophageal atresia\/stenosis and 87 cases of small intestinal atresia\/stenosis (31 duodenal, 56 jejuno\u2010ileal) were identified. Prevalences were 1.97 for esophageal atresia\/stenosis and 2.23 for small intestinal atresia\/stenosis (0.83 for duodenal atresia\/stenosis and 1.49 for jejuno\u2010ileal atresia\/stenosis) per 10\u2009000 births, respectively. The prevalence of esophageal atresia\/stenosis increased significantly from 1993\u20132001 to 2002\u20132011 (relative risk [<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>], 1.6), as did the prevalences of duodenal atresia\/stenosis (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>, 2.2) and jejuno\u2010ileal atresia\/stenosis (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>, 3.1). Chromosomal anomalies, particularly trisomy 21, were seen significantly more often in association with duodenal atresia\/stenosis (55%) than with esophageal atresia\/stenosis (28%, <jats:italic>P<\/jats:italic> &lt; 0.01) or jejuno\u2010ileal atresia\/stenosis (2%, <jats:italic>P<\/jats:italic> &lt; 0.01). The proportion of patients associated with prenatally diagnosed chromosomal anomaly was higher compared to postnatal diagnosis (<jats:italic>P<\/jats:italic> &lt; 0.01) in the esophageal atresia\/stenosis group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence of esophageal and small intestinal atresia\/stenosis increased significantly from 1993\u20132001 to 2002\u20132011. Prenatally diagnosed esophageal atresia\/stenosis is associated with multiple anomalies, particularly chromosomal anomalies, compared to other small intestine atresia\/stenosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12359","type":"journal-article","created":{"date-parts":[[2014,4,15]],"date-time":"2014-04-15T08:30:44Z","timestamp":1397550644000},"page":"838-844","source":"Crossref","is-referenced-by-count":34,"title":["Population\u2010based study of esophageal and small intestinal atresia\/stenosis"],"prefix":"10.1111","volume":"56","author":[{"given":"Daijiro","family":"Takahashi","sequence":"first","affiliation":[{"name":"Division of Neonatology Nagano Children's Hospital  Nagano Japan"},{"name":"Division of Pediatrics Fukuda Hospital  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehiko","family":"Hiroma","sequence":"additional","affiliation":[{"name":"Division of Neonatology Nagano Children's Hospital  Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Takamizawa","sequence":"additional","affiliation":[{"name":"Department of Surgery Nagano Children's Hospital  Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiko","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Division of Neonatology Nagano Children's Hospital  Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,9,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-010-0108-1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-2-24"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420480508"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2004.02.025"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhe.2003.12.017"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420520104"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.112249"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8628(20000828)93:5<355::AID-AJMG3>3.0.CO;2-Q"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19990312)83:2<117::AID-AJMG7>3.0.CO;2-4"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.68.6.743"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420520408"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhe.2004.07.008"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-30158"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2011-300597"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-011-3014-1"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.90008"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1886"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2007.10.028"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.341"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1070"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1754.1998.00208.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(00)70234-1"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19980605)77:5<431::AID-AJMG15>3.0.CO;2-J"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0890-6238(93)90085-L"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.1370110205"},{"key":"e_1_2_6_27_1","first-page":"485","article-title":"Epidemiological study of intestinal atresias: Central\u2010eastern France Registry 1976\u20131992","volume":"25","author":"Francannet C","year":"1996","journal-title":"J. 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