{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T02:52:24Z","timestamp":1716864744873},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,11,10]],"date-time":"2014-11-10T00:00:00Z","timestamp":1415577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The use of nuclear medicine for the management of malignant tumor, such as radioguided surgery and sentinel lymph node biopsy (<jats:styled-content style=\"fixed-case\">SLNB<\/jats:styled-content>), has been widely accepted in the adult practice. However, there are very few studies to apply those techniques for pediatric diseases. The aim of this study was to investigate the feasibility of application of nuclear medicine in surgery for neuroblastoma (<jats:styled-content style=\"fixed-case\">NB<\/jats:styled-content>) or rhabdomyosarcoma (<jats:styled-content style=\"fixed-case\">RMS<\/jats:styled-content>) in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Radioguided surgery using <jats:sup>123<\/jats:sup><jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>\u2010metaiodobenzylguanidine was performed on six children with <jats:styled-content style=\"fixed-case\">NB<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">SLNB<\/jats:styled-content> using technetium\u2010labeled tin or sulfur colloid was performed on two children with perineal <jats:styled-content style=\"fixed-case\">RMS<\/jats:styled-content>. Histological evaluation of resected specimens was performed to determine the accuracy of intraoperative detection and <jats:styled-content style=\"fixed-case\">SLNB<\/jats:styled-content>. All patients were evaluated for overall survival and complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Intraoperative tumor localization using hand\u2010held gamma probe was helpful in 85.7% of <jats:styled-content style=\"fixed-case\">NB<\/jats:styled-content> patients. Sensitivity and specificity of this technique were 81.8% and 93.3%, respectively. There were no postoperative complications, and four out of five patients with high\u2010risk <jats:styled-content style=\"fixed-case\">NB<\/jats:styled-content> experienced disease\u2010free survival (median follow up, 57 months). Sentinel lymph nodes were easily detected in patients with perineal <jats:styled-content style=\"fixed-case\">RMS<\/jats:styled-content>, and histological assessment revealed complete consistency with regional lymph node status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Nuclear medicine may have a potential application in the use of less invasive surgery for advanced <jats:styled-content style=\"fixed-case\">NB<\/jats:styled-content> or perineal <jats:styled-content style=\"fixed-case\">RMS<\/jats:styled-content>, the two most challenging pediatric malignancies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12368","type":"journal-article","created":{"date-parts":[[2014,4,28]],"date-time":"2014-04-28T12:06:38Z","timestamp":1398686798000},"page":"896-901","source":"Crossref","is-referenced-by-count":2,"title":["Application of nuclear medicine to achieve less invasive surgery for malignant solid tumors in children"],"prefix":"10.1111","volume":"56","author":[{"given":"Ryo","family":"Hotta","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery Keio University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takumi","family":"Fujimura","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Keio University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Shimojima","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Keio University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadaki","family":"Nakahara","sequence":"additional","affiliation":[{"name":"Department of Radiology Keio University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Fuchimoto","sequence":"additional","affiliation":[{"name":"Department of Surgery National Center for Child Health and Development  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Hoshino","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Keio University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhide","family":"Morikawa","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery International University of Health &amp; Welfare  Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Matsufuji","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Graduate School of Medicine Kagoshima University  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuo","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Keio University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(97)90201-4"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200005000-00014"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23016"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(95)90161-2"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(96)90686-7"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(98)70228-4"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199703)28:3<171::AID-MPO2>3.0.CO;2-G"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-007-0116-1"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1992.01420040034005"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2009.0012"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.40.3519"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2008.08.063"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-012-3066-x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200211000-00004"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2006.10.056"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.70.829.9059302"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-911X(200008)35:2<153::AID-MPO18>3.0.CO;2-7"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-009-4092-8"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2003.11.028"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2004.02.041"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2006.08.003"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(97)90466-8"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2002.36187"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2000.6936"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23403"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-003-0956-y"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21777"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-009-0393-9"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2003.50106"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-005-1592-5"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1053\/spsu.2001.24695"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0b013e318217ae2e"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.12368","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.12368","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.12368","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T17:22:45Z","timestamp":1696180965000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.12368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,10]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1111\/ped.12368"],"URL":"https:\/\/doi.org\/10.1111\/ped.12368","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,10]]}}}