{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T17:54:33Z","timestamp":1772819673369,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,9,16]],"date-time":"2014-09-16T00:00:00Z","timestamp":1410825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2014,10]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Several risk factors are attributed to retinopathy of prematurity (ROP<\/jats:styled-content>). This study was done to determine any association between hyperglycemia and ROP<\/jats:styled-content> in premature infants.<\/jats:p><\/jats:sec>Methods<\/jats:title>In a retrospective case\u2013control analysis, all infants with a gestational age (GA<\/jats:styled-content>)\u2009<\u200934 weeks and a birthweight (BW<\/jats:styled-content>)\u2009<\u20092000\u2009g admitted and treated in the N<\/jats:styled-content>eonatal I<\/jats:styled-content>ntensive C<\/jats:styled-content>are U<\/jats:styled-content>nit at A<\/jats:styled-content>mirkola C<\/jats:styled-content>hildren's H<\/jats:styled-content>ospital, I<\/jats:styled-content>ran, during M<\/jats:styled-content>arch 2007\u2013S<\/jats:styled-content>eptember 2010 were included. Hyperglycemia was defined as a plasma glucose level of >150\u2009mg\/dL during the hospital stay. The duration of being hyperglycemic was also recorded. All of these neonates were examined for ROP<\/jats:styled-content> by a retinologist unaware of group assignment. The difference in the ROP<\/jats:styled-content> incidence and also the severity of ROP<\/jats:styled-content> was compared between the hyperglycemic and non\u2010hyperglycemic infants. Matching was done for GA<\/jats:styled-content>, BW<\/jats:styled-content>, and also C<\/jats:styled-content>linical R<\/jats:styled-content>isk I<\/jats:styled-content>ndex for B<\/jats:styled-content>abies score. The data were analyzed by t<\/jats:italic>\u2010test, \u03c72<\/jats:sup>\u2010test and logistic regression test and a P<\/jats:italic> < 0.05 was considered significant.<\/jats:p><\/jats:sec>Results<\/jats:title>In total, 155 neonates were examined. Seventy (45.2%) of them developed ROP<\/jats:styled-content> but 85 (54.8%) did not show any evidence of ROP<\/jats:styled-content>. The frequency of hyperglycemia in patients with ROP<\/jats:styled-content> was 33 (47.2%), but in those without ROP<\/jats:styled-content>, hyperglycemia occurred in five (5.9%) (P<\/jats:italic> = 0.0001). The severity of ROP<\/jats:styled-content> showed no significant differences between the two groups (P<\/jats:italic> = 0.35). The logistic regression for GA<\/jats:styled-content> and BW<\/jats:styled-content> showed a significant correlation between hyperglycemia and ROP<\/jats:styled-content> (P<\/jats:italic> = 0.0001).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Hyperglycemia is an important risk factor for ROP<\/jats:styled-content> that can be prevented along with other risk factors by accurate supervision.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12371","type":"journal-article","created":{"date-parts":[[2014,5,7]],"date-time":"2014-05-07T04:50:51Z","timestamp":1399438251000},"page":"726-730","source":"Crossref","is-referenced-by-count":30,"title":["Correlation between hyperglycemia and retinopathy of prematurity"],"prefix":"10.1111","volume":"56","author":[{"given":"Mousa","family":"Ahmadpour\u2010Kacho","sequence":"first","affiliation":[{"name":"Non\u2010Communicable Pediatric Diseases Research Center Department of Pediatrics Babol University of Medical Sciences Babol IR Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Jashni Motlagh","sequence":"additional","affiliation":[{"name":"Amirkola Children's Hospital Department of Pediatrics Babol University of Medical Sciences Babol IR Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Ahmad","family":"Rasoulinejad","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Babol University of Medical Sciences Babol IR Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tahereh","family":"Jahangir","sequence":"additional","affiliation":[{"name":"Amirkola Children's Hospital Babol University of Medical Sciences Babol IR Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Bijani","sequence":"additional","affiliation":[{"name":"Non\u2010Communicable Pediatric Diseases Research Center Babol University of Medical Sciences Babol IR Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yadollah","family":"Zahed Pasha","sequence":"additional","affiliation":[{"name":"Non\u2010Communicable Pediatric Diseases Research Center Department of Pediatrics Babol University of Medical Sciences Babol IR Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,9,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211594"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1985.02140100045025"},{"key":"e_1_2_6_4_1","first-page":"236","article-title":"Risk factors of threshold retinopathy of prematurity in preterm infants with bronchopulmonary dysplasia","volume":"8","author":"Kim S","year":"2001","journal-title":"J. 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