{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:56:36Z","timestamp":1789732596712,"version":"4.0.1"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T00:00:00Z","timestamp":1413936000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to investigate the prognosis of infants born to multiple pregnancies obtained by <jats:italic>in vitro<\/jats:italic> fertilization (<jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content>) or spontaneously.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The records of multiple pregnancies in <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>akirkoy Maternity and Children's Hospital between <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ebruary 2008 and <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>anuary 2009 were investigated. Maternal, perinatal and postnatal data of multiple pregnancies were evaluated. The congenital anomalies determined by physical examination and\/or imaging studies in the prenatal, natal and postnatal period and the difference between groups in terms of morbidity and mortality were investigated as well.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 401 spontaneous multiple pregnancies and 128 <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content> multiple pregnancies were included in the study. Rate of multiple pregnancies for live births and <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content> rate were 3.8% and 0.79%, respectively. The mean maternal age was 30.1 years (21\u201343) in the <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content> group and 27.9 years (13\u201343) in the spontaneous group (<jats:italic>P<\/jats:italic> &lt; 0.05). The cesarean delivery rate was 100% in the <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content> group and 78% in the spontaneous group (<jats:italic>P<\/jats:italic> = 0.002). Premature rupture of membranes rate was 9.8% in the <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content> group and 3.6% in the spontaneous group (<jats:italic>P<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Multiple pregnancies constitute an important health problem due to high perinatal risks and increased health costs. We found maternal age, premature rupture of membranes and cesarean delivery rate significantly high in the <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content> group. No significant differences were found between spontaneous and <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content> multiple pregnancies in terms of demographic features, hospitalization stay and rate, admission to neonatal intensive care unit, mortality and congenital malformation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12372","type":"journal-article","created":{"date-parts":[[2014,5,7]],"date-time":"2014-05-07T04:50:56Z","timestamp":1399438256000},"page":"735-741","source":"Crossref","is-referenced-by-count":5,"title":["Features of multiple pregnancies obtained by <i>in vitro<\/i> fertilization or spontaneously"],"prefix":"10.1111","volume":"56","author":[{"given":"Emel","family":"\u00c7akar","sequence":"first","affiliation":[{"name":"Department of Pediatrics Neonatology Unit  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sultan","family":"Kavuncuo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Neonatology Unit  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esin Y\u0131ld\u0131z","family":"Aldemir","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Neonatology Unit  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merih","family":"\u00c7etinkaya","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Neonatology Unit  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alper","family":"G\u00fczelta\u015f","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Pediatric Cardiology Unit  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fclseren","family":"Arslan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Pediatric Neurology Unit, Bak\u0131rk\u00f6y Maternity and Children's Hospital  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,22]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1","article-title":"Assisted reproductive technology surveillance\u2010United States, 2005","volume":"57","author":"Wright VC","year":"2008","journal-title":"MMWR Surveil. 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