{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T01:08:59Z","timestamp":1776560939793,"version":"3.51.2"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,11,25]],"date-time":"2014-11-25T00:00:00Z","timestamp":1416873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2014,12]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The aim of this study was to determine whether patterns of increases in serum interleukin\u20106 (IL<\/jats:styled-content>\u20106) and C<\/jats:styled-content>\u2010reactive protein (CRP<\/jats:styled-content>) levels at birth were associated with the development of white matter injury (WMI<\/jats:styled-content>) in preterm infants with a fetal inflammatory response (FIR<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>One hundred infants who were born at <32 weeks gestation and had funisitis, as determined by histological evidence of FIR<\/jats:styled-content>, were studied. Infants were divided into four groups according to IL<\/jats:styled-content>\u20106 and CRP<\/jats:styled-content> levels at birth, with cut\u2010off values of 200\u2009pg\/mL and 0.4\u2009mg\/dL, respectively. We compared the incidence of WMI<\/jats:styled-content>, determined by MRI<\/jats:styled-content> at term\u2010equivalent age, among these groups.<\/jats:p><\/jats:sec>Results<\/jats:title>The number of infants in each group was 12, 43, 0, and 45 in the high IL<\/jats:styled-content>\u20106 and high CRP<\/jats:styled-content> (HH<\/jats:styled-content>) group, high IL<\/jats:styled-content>\u20106 and low CRP<\/jats:styled-content> (HL<\/jats:styled-content>) group, low IL<\/jats:styled-content>\u20106 and high CRP<\/jats:styled-content> (LH<\/jats:styled-content>) group, and low IL<\/jats:styled-content>\u20106 and low CRP<\/jats:styled-content> (LL<\/jats:styled-content>) group, respectively. The incidence of WMI<\/jats:styled-content> was significantly higher in the HH<\/jats:styled-content> group than in the HL<\/jats:styled-content> group and LL<\/jats:styled-content> group (83%, 40%, and 34%, respectively). Multiple logistic regression analysis revealed that a combined elevation in IL\u20106 and CRP<\/jats:styled-content> levels was an independent predictor for the development of WMI<\/jats:styled-content> (odds ratio, 8.3).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>A combined elevation in serum IL<\/jats:styled-content>\u20106 and CRP<\/jats:styled-content> levels at birth was associated with the development of WMI<\/jats:styled-content> in preterm infants with FIR<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12376","type":"journal-article","created":{"date-parts":[[2014,5,16]],"date-time":"2014-05-16T09:08:18Z","timestamp":1400231298000},"page":"851-855","source":"Crossref","is-referenced-by-count":21,"title":["Patterns of increases in interleukin\u20106 and C<\/scp>\u2010reactive protein as predictors for white matter injury in preterm infants"],"prefix":"10.1111","volume":"56","author":[{"given":"Kei","family":"Inomata","sequence":"first","affiliation":[{"name":"Department of Neonatology Hyogo Prefectural Kobe Children's Hospital Perinatal Center Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masami","family":"Mizobuchi","sequence":"additional","affiliation":[{"name":"Department of Neonatology Hyogo Prefectural Kobe Children's Hospital Perinatal Center Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Neonatology Hyogo Prefectural Kobe Children's Hospital Perinatal Center Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sota","family":"Iwatani","sequence":"additional","affiliation":[{"name":"Department of Neonatology Hyogo Prefectural Kobe Children's Hospital Perinatal Center Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitomi","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Neonatology Hyogo Prefectural Kobe Children's Hospital Perinatal Center Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Yoshimoto","sequence":"additional","affiliation":[{"name":"Department of Neonatology Hyogo Prefectural Kobe Children's Hospital Perinatal Center Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideto","family":"Nakao","sequence":"additional","affiliation":[{"name":"Department of Neonatology Hyogo Prefectural Kobe Children's Hospital Perinatal Center Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,25]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2006.108837"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.65.10.1291"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199911000-00013"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2006.001"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-0528.2003.00063.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(96)70585-9"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.06.086"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/jmf.11.1.18.25"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1373\/49.1.60"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-195902030-00010"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80282-0"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(16)34975-6"},{"key":"e_1_2_5_14_1","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/B978-1-4160-3995-2.10008-1","volume-title":"Neurology of the Newborn","author":"Volpe JJ","year":"2008"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa053792"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2005.05.002"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.172.2.2664864"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.116689"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.03.034"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2009.10.002"},{"key":"e_1_2_5_21_1","first-page":"805","article-title":"White matter injury in the premature infant: a comparison between serial cranial sonographic and MR findings at term","volume":"24","author":"Inder TE","year":"2003","journal-title":"AJNR Am. 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