{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T10:57:14Z","timestamp":1773658634692,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,9,24]],"date-time":"2014-09-24T00:00:00Z","timestamp":1411516800000},"content-version":"vor","delay-in-days":54,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic><jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>nterococcus faecalis<\/jats:italic> is rarely involved in neonatal meningitis. Several studies have indicated that the cytokines related to bacterial infection may induce nerve cell damage; therefore, the cytokine levels in cerebrospinal fluid (<jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>) could represent a valuable hallmark for rapid recognition of the disease and evaluation of the degree of neurological involvement. We analyzed cytokine levels in the <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> of a neonate with <jats:italic><jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>.\u2009faecalis<\/jats:italic> meningitis over time. Tumor necrosis factor\u2010\u03b1 (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1) tended to be elevated during the acute phase of infection, and then decreased during the convalescent stage after treatment. CSF inflammatory cytokine measurement may provide important clues for predicting the development of complications in the host because some of these cytokines, such as <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1, can injure neurons.<\/jats:p>","DOI":"10.1111\/ped.12398","type":"journal-article","created":{"date-parts":[[2014,9,24]],"date-time":"2014-09-24T06:25:25Z","timestamp":1411539925000},"source":"Crossref","is-referenced-by-count":5,"title":["Measurement of cytokine levels in cerebrospinal fluid over time in neonatal <i><scp>E<\/scp>nterococcal<\/i> meningitis"],"prefix":"10.1111","volume":"56","author":[{"given":"Naho","family":"Ikeda","sequence":"first","affiliation":[{"name":"Neonatal Center Juntendo University Shizuoka Hospital  Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Suganuma","sequence":"additional","affiliation":[{"name":"Neonatal Center Juntendo University Shizuoka Hospital  Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natsuki","family":"Ohkawa","sequence":"additional","affiliation":[{"name":"Neonatal Center Juntendo University Shizuoka Hospital  Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Nagata","sequence":"additional","affiliation":[{"name":"Neonatal Center Juntendo University Shizuoka Hospital  Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromichi","family":"Shoji","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiaki","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,9,24]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.88.3.F179"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/516909"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.3.837"},{"key":"e_1_2_5_5_1","first-page":"846","article-title":"Bacterial meningitis: pathogenesis, pathophysiology, and progress","volume":"327","author":"Quagliarello V","year":"1992","journal-title":"N. 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