{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T04:31:14Z","timestamp":1722486674339},"reference-count":11,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T00:00:00Z","timestamp":1413936000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Adverse drug reactions are the major cause of morbidity and mortality worldwide. Cutaneous drug reaction is the most common type of adverse reaction. Toxic epidermal necrolysis (<jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>) is a rare, life\u2010threatening mucocutaneous disease, usually attributable to drugs. There is no proven therapy for <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>. The mainstay of therapy is immediate withdrawal of the culprit drug, using disease\u2010modifying agents, and meticulous supportive care. Several disease\u2010modifying agents have been used such as steroid, i.v. human immunoglobulin (<jats:styled-content style=\"fixed-case\">IVIg<\/jats:styled-content>), plasmapheresis. A 10\u2010year\u2010old epileptic girl was admitted with lamotrigine\u2010induced <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>. She was unresponsive to steroid. Her condition deteriorated despite <jats:styled-content style=\"fixed-case\">IVIg<\/jats:styled-content> treatment. She was treated with <jats:italic><jats:styled-content style=\"fixed-case\">N<\/jats:styled-content><\/jats:italic>\u2010acetylcysteine (<jats:styled-content style=\"fixed-case\">NAC<\/jats:styled-content>). To our knowledge this is the first report of a child with <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>, a potentially lethal disorder, treated with <jats:styled-content style=\"fixed-case\">NAC<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">NAC<\/jats:styled-content> may be effective for children with <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/ped.12410","type":"journal-article","created":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T06:49:30Z","timestamp":1413960570000},"source":"Crossref","is-referenced-by-count":10,"title":["Toxic epidermal necrolysis treated with <i><scp>N<\/scp><\/i>\u2010acetylcysteine"],"prefix":"10.1111","volume":"56","author":[{"given":"Haluk","family":"Yavuz","sequence":"first","affiliation":[{"name":"Department of Pediatrics Necmettin Erbakan University Meram Medical Faculty  Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melike","family":"Emiroglu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Necmettin Erbakan University Meram Medical Faculty  Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,10,22]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0009922808320703"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2007.01.011"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2007.061465"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.08.039"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2007.06.006"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701033"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2005.00381.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.118557"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2004.04.007"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1997.tb02175.x"},{"key":"e_1_2_5_12_1","first-page":"51","article-title":"Review of intravenous immunoglobulin in the treatment of Stevens\u2010Johnson syndrome and toxic epidermal necrolysis","volume":"2","author":"Momin SB","year":"2009","journal-title":"J. Clin. Aesthet. Dermatol."}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.12410","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.12410","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T12:25:34Z","timestamp":1696163134000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.12410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":11,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1111\/ped.12410"],"URL":"https:\/\/doi.org\/10.1111\/ped.12410","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10]]}}}