{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T22:50:06Z","timestamp":1784242206592,"version":"3.55.0"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,2,25]],"date-time":"2015-02-25T00:00:00Z","timestamp":1424822400000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sickle cell disease (<jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>) is associated with sensorineural hearing loss (<jats:styled-content style=\"fixed-case\">SNHL<\/jats:styled-content>). Although the hearing loss is usually mild, some develop severe\u2010to\u2010profound hearing loss, in whom cochlear implants (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) may be an option. We present the cases of two children with <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> who developed bilateral severe\u2010to\u2010profound <jats:styled-content style=\"fixed-case\">SNHL<\/jats:styled-content> and underwent cochlear implantation. One patient became profoundly deaf after an acute episode of dizziness. Imaging indicated bilateral cochlear ossification, making subsequent cochlear implant surgery challenging. The second patient developed bilateral severe\u2010to\u2010profound <jats:styled-content style=\"fixed-case\">SNHL<\/jats:styled-content> following acute vaso\u2010occlusive crises. She went on to have uncomplicated cochlear implant surgery. These cases illustrate the variable manner in which children with <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> may develop <jats:styled-content style=\"fixed-case\">SNHL<\/jats:styled-content>, and the difficulties associated with managing such cases. We recommend that children with <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> should undergo regular audiological assessment. Furthermore, clinicians should be aware of the risk of cochlear fibrosis and ossification and ensure prompt assessment following an acute vaso\u2010occlusive crisis or unexplained vestibulocochlear event.<\/jats:p>","DOI":"10.1111\/ped.12413","type":"journal-article","created":{"date-parts":[[2015,2,25]],"date-time":"2015-02-25T06:13:30Z","timestamp":1424844810000},"page":"174-176","source":"Crossref","is-referenced-by-count":7,"title":["Cochlear implantation in children with sickle cell disease"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8082-3821","authenticated-orcid":false,"given":"Thomas","family":"Ashfield","sequence":"first","affiliation":[{"name":"Auditory Implant Centre St Thomas' Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irumee","family":"Pai","sequence":"additional","affiliation":[{"name":"Auditory Implant Centre St Thomas' Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Wilson","sequence":"additional","affiliation":[{"name":"Auditory Implant Centre St Thomas' Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anzel","family":"Britz","sequence":"additional","affiliation":[{"name":"Auditory Implant Centre St Thomas' Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Connor","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging St Thomas' Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alec","family":"Fitzgerald\u2010O'Connor","sequence":"additional","affiliation":[{"name":"Auditory Implant Centre St Thomas' Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Auditory Implant Centre St Thomas' Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,25]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1044\/1092-4388(2005\/059)"},{"key":"e_1_2_4_3_1","volume-title":"Standards for the Clinical Care of Adults with Sickle Cell Disease in the UK","author":"Sickle Cell Society","year":"2008"},{"key":"e_1_2_4_4_1","first-page":"285","article-title":"Sensorineural hearing loss in sickle cell disease patients in Sicily","volume":"57","author":"Samperi P","year":"2005","journal-title":"Minerva Pediatr."},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215108003617"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-196912000-00013"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948709600304"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.5144\/1658-3876.2011.97"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S002221510600377X"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.12.029"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e3181e71310"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.12413","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.12413","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.12413","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T00:44:52Z","timestamp":1695516292000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.12413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1111\/ped.12413"],"URL":"https:\/\/doi.org\/10.1111\/ped.12413","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2]]}}}